- Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate
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Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ
- KMID: 2471036
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):149-156.
- doi: 10.4196/kjpp.2020.24.2.149
Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS... -
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- The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1
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Cui F, Zhou Q, Xiao K, Ma S
- KMID: 2470917
- Yonsei Med J.
- 2020 Mar;61(3):210-217.
- doi: 10.3349/ymj.2020.61.3.210
PURPOSE: The goal of this study was to explore the effects of hsa-let-7g on cell proliferation and apoptosis, and elucidate its role in lung cancer development. MATERIALS AND METHODS: The expression... -
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- Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
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Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS
- KMID: 2470965
- Diabetes Metab J.
- 2020 Feb;44(1):173-185.
- doi: 10.4093/dmj.2018.0211
BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated... -
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- Downregulation of N-myc and STAT Interactor Protein Predicts Aggressive Tumor Behavior and Poor Prognosis in Invasive Ductal Carcinoma
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Choi JE, Hyun CL, Jin MS, Lee KM, Moon JH, Ryu HS
- KMID: 2470880
- J Breast Cancer.
- 2020 Feb;23(1):36-46.
- doi: 10.4048/jbc.2020.23.e12
PURPOSE: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. The expression levels... -
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- Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
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Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ
- KMID: 2466340
- Yonsei Med J.
- 2020 Jan;61(1):85-93.
- doi: 10.3349/ymj.2020.61.1.85
PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor... -
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- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
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Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
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- Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
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Jeong I, Song J, Bae SY, Lee SK
- KMID: 2468811
- J Cancer Prev.
- 2019 Dec;24(4):217-223.
- doi: 10.15430/JCP.2019.24.4.217
BACKGROUND: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies... -
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- Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target
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Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ
- KMID: 2468809
- J Cancer Prev.
- 2019 Dec;24(4):197-207.
- doi: 10.15430/JCP.2019.24.4.197
BACKGROUND: BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and the higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive... -
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- Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
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Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S
- KMID: 2467417
- Asian Spine J.
- 2019 Dec;13(6):875-889.
- doi: 10.31616/asj.2019.0073
STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against... -
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- Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
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Cirilli I, Silvestri , Marcheggiani F, Olivieri F, Galeazzi R, Antonicelli R, Recchioni , Marcheselli F, Bacchetti , Tiano L, Orlando P
- KMID: 2466509
- Diabetes Metab J.
- 2019 Dec;43(6):893-897.
- doi: 10.4093/dmj.2018.0254
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation... -
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- Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
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Seo JB, Choi YK, Woo HI, Jung YA, Lee S, Lee S, Park M, Lee IK, Jung GS, Park KG
- KMID: 2466504
- Diabetes Metab J.
- 2019 Dec;43(6):830-839.
- doi: 10.4093/dmj.2018.0181
BACKGROUND: The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to... -
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- Immunosuppressive Effect of Exosomes from Mesenchymal Stromal Cells in Defined Medium on Experimental Colitis
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Ma ZJ, Wang YH, Li ZG, Wang Y, Li BY, Kang HY, Wu XY
- KMID: 2465884
- Int J Stem Cells.
- 2019 Nov;12(3):440-448.
- doi: 10.15283/ijsc18139
BACKGROUND AND OBJECTIVES: The exosomes released by mesenchymal stromal cells (MSCs) in classical FBS-containing media have been demonstrated as an alternative, cell-free therapy in various diseases including inflammatory bowel disease... -
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- G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells
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Cho E, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Choi HK, Chun YJ
- KMID: 2462887
- Biomol Ther.
- 2019 Nov;27(6):591-602.
- doi: 10.4062/biomolther.2019.063
Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA... -
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- Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
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Lee H, Lee M, Kim HK, Kim YO, Kwon JT, Kim HJ
- KMID: 2461039
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):467-474.
- doi: 10.4196/kjpp.2019.23.6.467
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead... -
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- Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1
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Zhang P, Yu J, Gui Y, Sun C, Han W
- KMID: 2460227
- Yonsei Med J.
- 2019 Nov;60(11):1093-1102.
- doi: 10.3349/ymj.2019.60.11.1093
PURPOSE: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the... -
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- Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α
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Oh C, Kim HJ, Kim HM
- KMID: 2461018
- J Periodontal Implant Sci.
- 2019 Oct;49(5):270-286.
- doi: 10.5051/jpis.2019.49.5.270
PURPOSE: Despite the well-known anti-inflammatory effects of vitamin D in periodontal health, its mechanism has not been fully elucidated. In the present study, the effect of vitamin D on strengthening... -
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- Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells
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Wang Q, Zang J, Huang X, Lu H, Xu W, Chen J
- KMID: 2460488
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):589-601.
- doi: 10.5056/jnm19136
BACKGROUND/AIMS: Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO)... -
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- RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells
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Kang MG, Park D, Han HY, Shim H, Hong Y, Moon J, Yoon S, Kwon B
- KMID: 2456230
- Ann Dermatol.
- 2019 Oct;31(5):530-537.
- doi: 10.5021/ad.2019.31.5.530
BACKGROUND: Androgenic alopecia (AGA) is the most common type of hair loss. It is likely inherited genetically and is promoted by dihydrotestosterone. 5α-reductase has been proven a good target through... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Immunohistochemical Study of Fas/Fas-ligand and Cadherin Expression in Basal Cell Carcinoma in Sun-Exposed and Sun-Protected Areas
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Kim JH, Suh HS, Choi YS
- KMID: 2465949
- Korean J Dermatol.
- 2019 Sep;57(8):425-432.
BACKGROUND: UV radiation is the most important risk factor in the development of basal cell carcinoma (BCC). However, the association between tumorigenesis and the progression of BCC and UV exposure... -
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