Lab Anim Res.  2012 Jun;28(2):83-90. 10.5625/lar.2012.28.2.83.

Effects of male silkworm pupa powder on the erectile dysfunction by chronic ethanol consumption in rats

Affiliations
  • 1Huvet Co. Ltd, Iksan, Korea.
  • 2Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea.
  • 3Clinical Trial Center, Chonbuk National University Hospital, Jeonju, Korea.
  • 4Department of Agricultural Biology, National Academy of Agricultural Science, Suwon, Korea.
  • 5Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Korea.
  • 6Center for Animal Resources Development, Wonkwang University, Iksan, Korea. kimoj@wku.ac.kr
  • 7Department of Urology, School of Medicine, Chonbuk National University, Jeonju, Korea. rain@jbnu.ac.kr

Abstract

Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED is now considered an early manifestation of atherosclerosis, and consequently, a precursor of systemic vascular disease. This study was designed to investigate the effects of male silkworm pupa powder (SWP) on the levels of nitric oxide synthase (NOS) expression, nitrite, and glutathione (GSH); lipid peroxidation; libido; and erectile response of the corpus cavernosum of the rat penis. We induced ED in the study animals by oral administration of 20% ethanol over 8 weeks. The SWP-treated male rats were divided into 3 groups that were orally administered 200, 400, and 800 mg/kg. The libido of the SWP-administered male rats was higher than that of the ethanol control group. In addition, the erectile response of the corpus cavernosum was restored in males on SWP administration, to a level similar to that of the normal group without ED. The testosterone concentration did not increase significantly. The lipid peroxidation in the corpus cavernosum of the male rats administered SWP decreased significantly. In contrast, compared to the ethanol group, SWP-administered male rats showed increased GSH levels in the corpus cavernosum. The level of nitrite and NOS expression in the corpus cavernosum of SWP-administered male rats increased significantly. These results indicated that SWP effectively restored ethanol-induced ED in male rats.

Keyword

Erectile dysfunction; libido activity; sexual function; silkworm pupa powder

MeSH Terms

Administration, Oral
Animals
Atherosclerosis
Bombyx
Erectile Dysfunction
Ethanol
Glutathione
Humans
Libido
Lipid Peroxidation
Male
Nitric Oxide Synthase
Penis
Pupa
Rats
Testosterone
Vascular Diseases
Ethanol
Glutathione
Nitric Oxide Synthase
Testosterone
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