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Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice

Yin GN

Purpose: To comprehensively evaluate the effect on angiogenesis of heme-binding protein 1 (Hebp1) in the treatment of diabetes-induced erectile dysfunction. Materials and Methods: Mouse corpus cavernosum endothelial cells and pericytes were...
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Feasibility study of a novel rectal cooling system for hypothermic radical prostatectomy in a swine model

Song WH, Sun I, Jang G, Lee JH, Jeong JH, Lee JC, Kim HC, Jeong CW

Thermal damage and inflammatory responses of the sphincter and neurovascular bundles (NVBs) are responsible for post-prostatectomy incontinence and erectile dysfunction. Intraoperative hypothermia in the pelvic cavity may reduce the occurrence...
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Impact of Physical Exercise Program Interventions on Erectile Function and Cardiovascular Health in Males with Prostate Cancer

Chung E, Rhee H

Prostate cancer (PC) and its associated treatments can cause significant cardiovascular and sexual dysfunctions. While structured exercise interventions can induce positive outcomes in males with PC, there are limited data...
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Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury

Sorkhi S, Sanchez CC, Cho MC, Cho SY, Chung H, Park MG, Lahey S, Hsieh TC, Bhargava V, Rajasekaran MR

Purpose: Penile microvascular dysfunction is a known contributor to erectile dysfunction (ED) and penile fibrosis has been shown to impair microvascular perfusion (MVP). Our objectives were to: (i) determine beneficial...
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Estimation of Utility Weights for Prostate-related Health States in Korea

Kim SH, Ock M, Jo MW, Park S

Objectives: Very limited previous research has investigated the utility weights of prostate-related diseases in the general population in Korea. The purpose of this study was to calculate the utility of...
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A new strategy for stem cells therapy for erectile dysfunction: Adipose-derived stem cells transfect Neuregulin-1 gene through superparamagnetic iron oxide nanoparticles

Cheng J, Zheng Z, Tang W, Shao J, Jiang H, Lin H

Purpose: Our previous studies showed that nanotechnology improves derived adipose-derived stem cells (ADSCs) therapy for erectile dysfunction (ED). In this study, the Neuregulin-1(NRG1) gene was transfected into ADSCs with superparamagnetic...
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Relationships between erectile dysfunction, prostate cancer treatment type and inflatable penile prosthesis implantation

Shen C, Jain K, Shah T, Schaefer E, Zhou S, Fried D, Helmer DA, Sadeghi-Nejad H

Purpose: The prevalence of erectile dysfunction (ED) and the utilization of inflatable penile prosthesis (IPP) among prostate cancer patients are understudied. The aim of the study was to examine the...
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Ginseng for Erectile Dysfunction: A Cochrane Systematic Review

Lee HW, Lee MS, Kim TH, Alraek T, Zaslawski C, Kim JW, Moon DG

The objectives of this study were to assess the effects of ginseng on erectile dysfunction. We searched multiple electronic databases from their inceptions to 30 January 2021 without restrictions by...
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Efficacy and Safety of Mirodenafil Oro-Dispersible Film in Korean Patients with Erectile Dysfunction: A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter, Phase IV Study

Lee SW, Son H, Lee SW, Cho KS, Moon DG, Yang DY, Chung WS, Suh JK, Park HJ, Min K, Moon KH, Park K, Park JK, Hyun JS, Yang SK

Purpose: To investigate the efficacy, safety, and tolerability of oro-dispersible film (ODF) formulation of mirodenafil 50 mg and 100 mg for the treatment of patients with erectile dysfunction (ED) in...
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Erectile Dysfunction in Men With Adult Congenital Heart Disease: A Prevalent but Neglected Issue

Background and Objectives: For adult men with congenital heart disease (ACHD), data on erectile dysfunction (ED) is limited. We aimed to assess the frequency of ED, its role in patient-physician...
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Adjuvant daily therapy with L-arginine 2,500 mg and tadalafil 5 mg increases efficacy and duration of benefits of low-intensity extracorporeal shock wave therapy for erectile dysfunction: A prospective, randomized, single-blinded study with 1-year follow-up

Gallo L, Pecoraro S, Sarnacchiaro P

Purpose: To investigate a therapeutic protocol for erectile dysfunction (ED) based on the combination of low-intensity extracorporeal shock wave therapy (Li-ESWT), tadalafil, and L-arginine. Materials and Methods: Recruited patients completed the...
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The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review

Tseng CH

Metformin is the first-line oral antidiabetic drug that shows multiple pleiotropic effects of anti-inflamation, anti-cancer, antiaging, anti-microbia, anti-atherosclerosis, and immune modulation. Metformin’s effects on men’s related health are reviewed here,...
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Low Serum 25-Hydroxyvitamin D Level as a Potential Risk Factor of Erectile Dysfunction in Elderly Men with Moderate to Severe Lower Urinary Tract Symptoms

Kim HS, Cho MC

Purpose: To evaluate the correlation between vitamin D level and erectile dysfunction (ED) in male lower urinary tract symptoms (LUTS) patients. Materials and Methods: We analyzed data from 534 male patients...
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Impact of Sarcopenia on Erectile Function after Nerve-Sparing Robot-Assisted Radical Prostatectomy

Mitsui Y, Sadahira T, Maruyama Y, Sato R, Rodrigo AGH, Wada K, Araki M, Watanabe M, Watanabe T, Nasu Y

Purpose: To determine the impact of sarcopenia on erectile functional outcomes after a nerve-sparing (NS) robot-assisted radical prostatectomy (RARP) using patient-reported validated questionnaires. Materials and Methods: In this retrospective study, RARP...
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Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects

Lu YP, Fan S, Liang Z, Song Y, Liu K, Zhou K, Wang X, Kang J, Yang Y, Liu X

Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the...
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COVID-19 Endothelial Dysfunction Can Cause Erectile Dysfunction: Histopathological, Immunohistochemical, and Ultrastructural Study of the Human Penis

Kresch E, Achua J, Saltzman R, Khodamoradi K, Arora H, Ibrahim E, Kryvenko ON, Almeida VW, Firdaus F, Hare JM, Ramasamy R

Purpose: A pilot study to describe histopathological features of penile tissue of patients who recovered from symptomatic COVID-19 infection and subsequently developed severe erectile dysfunction (ED). Materials and Methods: Penile tissue...
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Erectile Dysfunction in Germ Cell Tumor Survivors

Okada K, Fujita K, Fukuhara S, Kiuchi H, Uemura M, Imamura R, Nonomura N

Purpose: Germ cell tumors (GCTs) are the most common malignant neoplasms in adolescents and young adults, and most patients with these tumors can be completely cured. Therefore, maintaining quality of...
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Restoration of Cavernous Veno-Occlusive Function through Chronic Administration of a Jun-Amino Terminal Kinase Inhibitor and a LIM-Kinase 2 Inhibitor by Suppressing Cavernous Apoptosis and Fibrosis in a Rat Model of Cavernous Nerve Injury: A Comparison with a Phosphodiesterase Type 5 Inhibitor

Cho MC, Lee J, Park J, Kim SW

Purpose: To determine if chronic administration of Jun-amino terminal kinase (JNK)-inhibitors and LIM-kinase 2 (LIMK2)-inhibitors from the immediate post-injury period in a rat model of cavernous-nerve-crush-injury could normalize cavernousveno-occlusive-function, and...
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Evaluation of Age- and Radical-Prostatectomy Related Changes in Male Pelvic Floor Anatomy Based on Magnetic Resonance Imaging and 3-Dimensional Reconstruction

Tai JW, Sorkhi SR, Trivedi I, Sakamoto K, Albo M, Bhargava V, Rajasekaran MR

Purpose: Puborectalis muscles (PRM) and ischiocavernosus muscles (ICM) play important roles in urinary continence and male erectile functions. Understanding of anatomy and surgical-injury related changes to these muscles is critical...
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Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study

Song SH, Shin DH, Her YS, Oh MH, Baek JW, Sung S, Eum JH, Heo Y, Kim DS

Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the...
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