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Characteristics and management of thrombotic microangiopathy in kidney transplantation

Cho W, Jo SK, Jung CW, Kim MG

Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries....
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Effects of rosiglitazone, an antidiabetic drug, on Kv3.1 channels

Lee HM, Yoon SH, Kim MG, Hahn SJ, Choi BH

Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the interaction of rosiglitazone with Kv3.1 expressed in Chinese hamster ovary cells using...
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Eculizumab as rescue therapy in a kidney transplant recipient with atypical hemolytic uremic syndrome: a case report

Oh YJ, Lee J, Kim Y, Jun H, Sim J, Kim MG, Jung CW

A 61-year-old female patient with chronic kidney disease due to diabetes mellitus and hypertension–induced nephropathy received a deceased donor kidney transplant in March 2020. In July 2020, she was transferred...
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Risk factors for 1-year low graft function after deceased donor kidney transplantation

Oh YJ, Jun H, Kim MG, Jung CW

Background: As the use of kidney grafts from extended criteria donors increases due to the shortage of donor organs, concerns about graft outcomes after kidney transplantation (KT) has been amplified....
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Impact of iliac artery calcification of deceased-donors on graft outcomes after kidney transplantation

Oh YJ, Jun H, Kim MG, Jung CW

Background: The quality of deceased donors (DDs) kidney is closely related to graft survival after kidney transplantation (KT). Vascular calcification is a highly regulated, cell-mediated process associated with chronic kidney...
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Analysis of prognostic factors through survival rate analysis of oral squamous cell carcinoma patients treated at the National Cancer Center: 20 years of experience

Choi YS, Kim MG, Lee JH, Park JY, Choi SW

Objectives: This study aimed to analyze the clinicopathological prognostic factors affecting the survival of patients with oral squamous cell carcinoma (OSCC). Materials and Methods: A retrospective study was conducted on patients...
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Stability of acetylsalicylic acid in human blood collected using volumetric absorptive microsampling (VAMS) under various drying conditions

Moon SJ, Han SH, Kwak YG, Kim MG

Acetylsalicylic acid (ASA) is one of the most commonly used medications in global market, with a risk of intoxication in certain patients. However, monitoring blood drug concentration often requires frequent...
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Comparison of international guidelines for early-phase clinical trials of cellular and gene therapy products

Shin W, Kim MG, Kim A

Cellular and gene therapies (CGT) are promising fields that are bringing significant clinical benefits to patients by directly targeting the underlying cause of disease. In line with this trend, regulatory...
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A Case Report of Thrombotic Thrombocytopenia After ChAdOx1 nCov-19 Vaccination and Heparin Use During Hemodialysis

Son YB, Kim TB, Min HJ, Lee J, Yang J, Kim MG, Jo SK, Cho WY, Oh SW

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but life-threatening complication. VITT strongly mimics heparin-induced thrombocytopenia (HIT) and shares clinical features. Heparin is commonly used to prevent coagulation during hemodialysis. Therefore,...
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Eculizumab as rescue therapy in a renal transplant recipient with atypical hemolytic uremic syndrome: a case report

Lee J, Gwon JG, Kim MG, Jung CW

Background: Atypical hemolytic uremic syndrome (aHUS) after kidney transplantation (KT) can cause irreversible graft failure by over-activation of the alternative complement pathway. Eculizumab is a humanized monoclonal antibody against the...
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Impact of tacrolimus trough level at discharge on acute rejection rate in sensitized renal transplant recipients: a national cohort study

Lee C, Gwon JG, Kim MG, Jung CW

Background: Tacrolimus (TAC) is one of the most important maintenance immunosuppressants in kidney transplantation (KT) and maintaining the proper blood concentration is essential to prevent acute rejection. Several studies have...
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Pharmacokinetic properties and bioequivalence of gefitinib 250 mg in healthy Korean male subjects

Moon SJ, Kim Y, Jeon JY, Park SJ, Kwak YG, Kim MG

Gefitinib is an anti-cancer drug used to treat non-small cell lung cancer. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 2 orally administered...
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Validation of LC-MS/MS method for determination of rosuvastatin concentration in human blood collected by volumetric absorptive microsampling (VAMS)

Moon SJ, Lee SE, Kwak YG, Kim MG

In light of the shift toward patient-centric clinical trials, a measure of simplifying blood collection process and minimizing the volume of blood samples is on the rise. Volumetric absorptive microsampling...
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A Comparative Study on the Treatment Effect of Lipo-Prostagladin with Hypertension and Diabetes Mellitus in Sudden Sensorineural Hearing Loss Patients

Heo HJ, Choi CH, Kim MG, Hong SH, Seo JW

Background and Objectives Several drugs which can improve blood flow have been used as treatment options for sudden sensorineural hearing loss (SSNHL) based on the theory that improvement of perfusion...
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Magnetic Resonance Imaging Images of the Local Anesthetic Spreading after Erector Spinae Plane Block at T2 Level

Kim MG

It has been reported that erector spinae plane block (ESPB), which was performed at the mid-thoracic level, can be effective for the visceral and somatic pain of the thoracic region....
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Dynamics of T Lymphocyte between the Periphery and the Brain from the Acute to the Chronic Phase Following Ischemic Stroke in Mice

Kim M, Kim SD, Kim KI, Jeon EH, Kim MG, Lim YR, Lkhagva-Yondon E, Oh Y, Na K, Chung YC, Jin BK, Song YS, Jeon MS

  • KMID: 2515814
  • Exp Neurobiol.
  • 2021 Apr;30(2):155-169.
  • doi: 10.5607/en20062
Stroke causes systemic immunosuppression. T lymphocytes are involved in infarct size in the early stages of stroke. However, the phenotypes of T lymphocytes and their functions in peripheral immune organs...
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Anesthetic considerations of Joubert syndrome in patients with mitochondrial disease - A case report -

Kim JY, Jeong K, Han KS, Park JE, Kim MG, Jun MR

Background Joubert syndrome and mitochondrial disease are rare congenital diseases in which a wide range of symptoms affects multiple organs. Patients with these diseases present characteristic symptoms related to the musculoskeletal,...
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Perforation on the superior side of duodenum is a risk factor of laparoscopic primary repair for duodenal ulcer perforation

Kim HI, Cho YJ, Yeom JH, Jeon WJ, Kim MG

Purpose: Primary repair is the standard surgical method for treating duodenal ulcer perforations, with very good results usually anticipated because of the simplicity of the associated surgical techniques. Therefore, this...
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Laparoscopic Small Bowel Resection After Percutaneous Aspiration Embolectomy in a Patient With Pan-Peritonitis Caused by Superior Mesenteric Artery Occlusion

Song JS, Kim MG

Acute mesenteric ischemia is a state in which intestinal infarction can be caused by a sudden decrease in blood flow. A 68-year-old man was transferred to Hanyang University Guri hospital...
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Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia

Lee J, Kim MG, Jeong HC, Shin KH

Clozapine has been used as a treatment of schizophrenia. Despite its large interindividual variability, few reports addressed the physiologically-based pharmacokinetic modeling and simulation (PBPK M&S) of clozapine in patients. This...
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