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Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach

Kim JH, Nam SJ, Park SC, Lee SH, Kim TS, Lee M, Park JM, Choi DH, Kang CD, Lee SJ, Ryu YJ, Lee K, Park SY

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):185-191.
  • doi: 10.4196/kjpp.2020.24.2.185
Interstitial cells of Cajal (ICC) are known as the pacemaker cells of gastrointestinal tract, and it has been reported that acute gastroenteritis induces intestinal dysmotility through antibody to vinculin, a...
The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts

Son E, Lee D, Woo CW, Kim YH

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):173-183.
  • doi: 10.4196/kjpp.2020.24.2.173
An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of...
Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

Jung JS, Kho AR, Lee SH, Choi BY, Kang SH, Koh JY, Suh SW, Song DK

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):165-171.
  • doi: 10.4196/kjpp.2020.24.2.165
Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma...
Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells

Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):157-163.
  • doi: 10.4196/kjpp.2020.24.2.157
Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the...
Inhibition of melanogenesis by sodium 2-mercaptoethanesulfonate

Kim JH, Oh CT, Kwon TR, Kim JH, Bak DH, Kim H, Park WS, Kim BJ

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):149-156.
  • doi: 10.4196/kjpp.2020.24.2.149
Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS...
Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression

Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):137-147.
  • doi: 10.4196/kjpp.2020.24.2.137
Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis...
Connecting the dots between SHP2 and glutamate receptors

Ryu HH, Kim SY, Lee YS

  • Korean J Physiol Pharmacol.
  • 2020 Mar;24(2):129-135.
  • doi: 10.4196/kjpp.2020.24.2.129
SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological...

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