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Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core

Kim WY, Cai WT, Jang JK, Kim JH

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):121-126.
  • doi: 10.4196/kjpp.2020.24.1.121
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases...
Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):111-119.
  • doi: 10.4196/kjpp.2020.24.1.111
In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4

Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):101-110.
  • doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With...
Feasibility of fully automated classification of whole slide images based on deep learning

Cho KO, Lee SH, Jang HJ

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):89-99.
  • doi: 10.4196/kjpp.2020.24.1.89
Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners...
Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus

Cho KO, Jeong KH, Cha JH, Kim SY

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):81-88.
  • doi: 10.4196/kjpp.2020.24.1.81
Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression...
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):69-79.
  • doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta

Kim SK, Avila JJ, Massett MP

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):53-68.
  • doi: 10.4196/kjpp.2020.24.1.53
The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON,...
Bordetella bronchiseptica is a potent and safe adjuvant that enhances the antigen-presenting capability of dendritic cells

Lee YJ, Han Y, Joo HG

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):47-52.
  • doi: 10.4196/kjpp.2020.24.1.47
We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could...
β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice

Ye JY, Li L, Hao QM, Qin Y, Ma CS

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):39-46.
  • doi: 10.4196/kjpp.2020.24.1.39
Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential...
Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

Lee B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):27-37.
  • doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but...
Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells

Wang LY, Wu J, Gao YF, Lin DM, Ma J

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):19-26.
  • doi: 10.4196/kjpp.2020.24.1.19
Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe...
Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43

Wang J, Bai T, Wang N, Li H, Guo X

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):11-18.
  • doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid...
Autophagy in neutrophils

Shrestha S, Lee JM, Hong CW

  • Korean J Physiol Pharmacol.
  • 2020 Jan;24(1):1-10.
  • doi: 10.4196/kjpp.2020.24.1.1
Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy...

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