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12 results

The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats

Jang HS, Jang IS, Lee MG

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):191-198.
  • doi: 10.4196/kjpp.2010.14.3.191
The effects of different doses of tramadol on analgesia and electroencephalographic (EEG) spectral parameters were compared in rats. Saline or tramadol 5, 10, 20 or 40 mg/kg was administered. The...
Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes: Involvement of IL-6 Independent Pathway

Lee JK, Seo EM, Lee SS, Park SH, Sim YB, Jung JS, Kim SM, Suh HW

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):185-189.
  • doi: 10.4196/kjpp.2010.14.3.185
The present study demonstrates the effect of fibrates, agonists of PPARalpha on cytokines-induced proliferation in primary cultured astrocytes. Alone or combination treatment with cytokines, such as IL-1beta (10 ng/ml), IFNgamma...
Tetrahydrobiopterin Inhibits PDGF-stimulated Migration and Proliferation in Rat Aortic Smooth Muscle Cells via the Nitric Oxide Synthase-independent Pathway

Jiang X, Kim B, Lin H, Lee CK, Kim J, Kang H, Lee P, Jung SH, Lee HM, Won KJ

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):177-183.
  • doi: 10.4196/kjpp.2010.14.3.177
Tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS) activity, is known to play important roles in modulating both NO and superoxide production during vascular diseases such as atherosclerosis....
Hyperosmotic Stimulus Down-regulates 1alpha, 25-dihydroxyvitamin D3-induced Osteoclastogenesis by Suppressing the RANKL Expression in a Co-culture System

Tian YS, Jeong HJ, Lee SD, Kong SH, Ohk SH, Yoo YJ, Seo JT, Shin DM, Sohn BW, Lee SI

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):169-176.
  • doi: 10.4196/kjpp.2010.14.3.169
The hyperosmotic stimulus is regarded as a mechanical factor for bone remodeling. However, whether the hyperosmotic stimulus affects 1alpha, 25-dihydroxyvitamin D3 (1alpha,25(OH)2D3)-induced osteoclastogenesis is not clear. In the present study,...
Morinda citrifolia Inhibits Both Cytosolic Ca2+-dependent Phospholipase A2 and Secretory Ca2+-dependent Phospholipase A2

Song HS, Park SH, Ko MS, Jeong JM, Sohn UD, Sim SS

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):163-167.
  • doi: 10.4196/kjpp.2010.14.3.163
This study investigated the effects of the methanol extracts of Morinda citrifolia containing numerous anthraquinone and iridoid on phospholipase A2 (PLA2) isozyme. PLA2 activity was measured using various PLA2 substrates,...
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice

Kim HJ, Jung JI, Kim Y, Lee JS, Yoon YW, Kim J

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):157-161.
  • doi: 10.4196/kjpp.2010.14.3.157
Heat shock proteins (HSPs) are specifically induced by various forms of stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful...
The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats

Ameer NH, Lee JH, Choi MA, Jin GS, Kim MS, Park BR

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):151-156.
  • doi: 10.4196/kjpp.2010.14.3.151
This study was performed to investigate the role of glutamate neurotransmitter system on gastrointestinal motility in a middle cerebral artery occlusion (MCAO) model of rats. The right middle cerebral artery...
Regulation of Adenosine-activated GIRK Channels by Gq-coupled Receptors in Mouse Atrial Myocytes

Cho H

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):145-150.
  • doi: 10.4196/kjpp.2010.14.3.145
Adenosine (Ado) is an important mediator of the endogenous defense against ischemia-induced injury in the heart. The action of Ado is mediated by activation of G protein-gated inwardly rectifying K+...
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells

Yoo DG, Kim CS, Lee SK, Kim HS, Cho EJ, Park MS, Lee SD, Park JB, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):139-144.
  • doi: 10.4196/kjpp.2010.14.3.139
In this study, we evaluated the role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the tumor necrosis factor-alpha (TNF-alpha) induced cyclooxygenase-2 (COX-2) expression using A549 lung adenocarcinoma cells. TNF-alpha induced the...
Stimulatory Effects of Ginsan on the Proliferation and Viability of Mouse Spleen Cells

Ko EJ, Joo HG

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):133-137.
  • doi: 10.4196/kjpp.2010.14.3.133
Ginsan is an acidic polysaccharide purified from Panax ginseng, a famous oriental herb. Although a variety of biological activities of ginsan have been studied, the effects of ginsan on spleen...
Modulation of Presynaptic GABA Release by Oxidative Stress in Mechanically-isolated Rat Cerebral Cortical Neurons

Hahm ET, Seo JW, Hur J, Cho YW

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):127-132.
  • doi: 10.4196/kjpp.2010.14.3.127
Reactive oxygen species (ROS), which include hydrogen peroxide (H2O2), the superoxide anion (O2-.), and the hydroxyl radical (OH.), are generated as by-products of oxidative metabolism in cells. The cerebral cortex...
A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K+ Channels in Rabbit Ventricular Myocytes

Park WS, Son YK, Ko EA, Choi SW, Kim N, Choi TH, Youn HJ, Jo SH, Hong DH, Han J

  • Korean J Physiol Pharmacol.
  • 2010 Jun;14(3):119-125.
  • doi: 10.4196/kjpp.2010.14.3.119
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K+ current (I(K)) using the patch clamp technique....

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