Korean J Physiol Pharmacol.  2012 Apr;16(2):119-123. 10.4196/kjpp.2012.16.2.119.

Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Affiliations
  • 1Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Korea. hwsuh@hallym.ac.kr
  • 2Department of Pharmacology, College of Medicine, Hallym University, Chuncheon 200-702, Korea.
  • 3Department of Pharmacology, College of Medicine, Translational Research Center, Institute of Bio-Science and Technology, Dankook University, Cheonan 330-714, Korea.

Abstract

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 microg) was diminished by Agrimonia pilosa Ledeb extract. Intraperitoneal (i.p.) pretreatment with yohimbine (alpha2-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Agrimonia pilosa Ledeb extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Agrimonia pilosa Ledeb extract in the writhing test. Our results suggest that Agrimonia pilosa Ledeb extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Agrimonia pilosa Ledeb extract may be mediated by alpha2-adrenergic receptor, but not opioidergic and serotonergic receptors.

Keyword

Agrimonia pilosa Ledeb; Anti-nociception; Inflammatory pain; alpha2 adrenoceptor
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