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Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression

Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q

Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis...
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Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH

STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus...
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Genome Shuffling of Mangrove Endophytic Aspergillus luchuensis MERV10 for Improving the Cholesterol-Lowering Agent Lovastatin under Solid State Fermentation

El-Gendy M, Al-Zahrani HAA, El-Bondkly AMA

In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran....
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Oral Lovastatin Attenuates Airway Inflammation and Mucus Secretion in Ovalbumin-Induced Murine Model of Asthma

Liou CJ, Cheng PY, Huang WC, Chan CC, Chen MC, Kuo ML, Shen JJ

PURPOSE: Lovastatin is an effective inhibitor of cholesterol synthesis. A previous study demonstrated that lovastatin can also suppress airway hyperresponsiveness (AHR) in murine model of asthma. We aimed to investigate...
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Effects of lovastatin on free fatty acid oxidation in human skeletal muscle cells

Kim DL, Song KH, Kim SK, Kim HR, Ciaraldi T, Henry RR

  • KMID: 2081277
  • Korean J Med.
  • 2007 Jun;72(6):600-606.
BACKGROUDN: Recent clinical studies have suggested that statins improve insulin resistance and glucose metabolism in the skeletal muscle of diabetic patients. To evaluate a possible component of this action, we...
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Effects of Lovastatin on Free Fatty Acid Oxidation in Cultured L6 Rat Skeletal Muscle Cells

Kim DL, Song KH, Kim HR, Kim SK

BACKGROUND: Recent clinical studies suggest that statins improve insulin resistance and glucose metabolism in patients with metabolic syndrome and type 2 diabetes. To evaluate the possible mechanism of this action,...
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Three Cases of Lovastatin Induced Rhabdomyolysis Following Renal Transplantation

Kim YH, Kim HJ, Lee G, Choi CW, Lee TW, Ihm CG, Kim MJ

  • KMID: 2198988
  • J Korean Soc Transplant.
  • 2001 Dec;15(2):246-250.
In renal transplantation, cardiovascular disease is a frequent cause of mortality and morbidity. Post-transplant lipoprotein abnormalities may contribute to the development of cardiovascular disease and chronic renal allograft rejection. Post-...
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Effect of Enalapril or Lovastatin on Tubulointerstitial Injury Induced by Protein-overload Proteinuria in Rats

Chung SJ, Chung JG, Yang WS, Kim SB, Park SK, Lee SK, Park JS

  • KMID: 1989745
  • Korean J Nephrol.
  • 2001 May;20(3):393-402.
BACKGROUND: Previous studies have demonstrated that enalapril or lovastatin seems to ameliorate the renal injury in several animal models with glomerulonephritis. The aim of this study was to examine whether...
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Effects of Individual or Combined Treatment with Enalapril and Lovastatin on the Osteopontin Gene Expression in 5/6 Nephrectomized Rats

Kim SB, Park JS, Yang WS, Park SK, Lee SK, Lee JS

  • KMID: 2307278
  • Korean J Nephrol.
  • 1999 Nov;18(6):877-886.
Osteopontin, a secreted, arginine-glycin-asparate (RGD)-containing phosphoprotein is up-regulated in renal cortex in many experimental models of tubu- lointerstitial fibrosis. Osteopontine gene seems to be induced predominantly in chronic and progressive...
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Effect of Local Administration of Lovastatin on Preventing Neointimal Hyperplasia in the Rat Carotid Artery Injury Model

Lee SC, Kim DK, Park SW, Huh JE, Park SJ, Gwon HC, Kim JS, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

BACKGROUND AND OBJECTIVES: ovastatin, a HMG-CoA reductase inhibitor, is known to show antiproliferative effects on VSMC after vessel injury, but a large amount of the drug is needed orally for...
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Effect of Local Administration of Lovastatin on Preventing Neointimal Hyperplasia in the Rat Carotid Artery Injury Model

Hwang GS, Kim YH, Lee HS, Kim BS, Lee SJ, Pak HN, Lim DS, Park CG, Seo HS, Shim WJ, Oh DJ, Ro YM

BACKGROUND AND OBJECTIVES: ovastatin, a HMG-CoA reductase inhibitor, is known to show antiproliferative effects on VSMC after vessel injury, but a large amount of the drug is needed orally for...
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Antiproliferative Effect of Lovastatin on Vascular Smooth Muscle Cell

Park SW, Kim DK, Huh JE, Choi YH, Choi YH, Gwon HC, Kim JS, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

BACKGROUND AND OBJECTIVES: This study was performed to investigate the antiproliferative effect of lovastatin on vascular smooth muscle cell, especially to determine whether lovastatin induces apoptosis in vascular smooth muscle...
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Effects of Lovastatin in Combination with 5-FU on Stomach Cancer Cells

Park C, Kang WK

  • KMID: 2059145
  • J Korean Cancer Assoc.
  • 1997 Oct;29(5):785-790.
No abstract available
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Effects of lovastatin on serum lipids of patients with primary hypercholesterolemia

Kim KS, Kim JH, Lim HK, Lee BH, Lee JK

  • KMID: 1691757
  • Korean J Crit Care Med.
  • 1993 Jun;8(1):7-11.
No abstract available.
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Clinical Efficacy of Lovastatin in Patients with Hypercholesterolemia

Kim JS, Chai IH, Park SW, Hong SK, Kim HS, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW

BACKGROUND: This study was designed to evaluate the clinical efficasy of lovastatin, HMG-CoA reductase inhibitor, in patients with hypercholesterolemia. METHODS AND RESULTS: Lovastatin 20 to 80 mg were administered once daily...
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The effects of lovastatin on puromycin aminonucleoside-induced focal segmental glomerulosclerosis in rats

Kim MJ, Choi IJ

  • KMID: 1694942
  • Korean J Nephrol.
  • 1991 Dec;10(4):492-504.
No abstract available.
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Effect of Lovastatin on Serum Lipids in Primary Hypercholesterolemia

Park WH, Kim SW, Woo EJ, Kang SW, Hwang JY, Chae SC, Jun JE

10 Patients with primary hypercholesterolemia were treated for 12 weeks with lovastation(20mg t.i.d). Lovastatin reduced mean total and low density lipoprotein cholesterol by 43% and 57% respectively(p
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Hypolipidemic Effects and Safety of Lovastatin in Patients with Primary Hypercholesterolemia

Bae JH, Choue CW, Kim KS, Kim MS, Song JS

To evaluate the efficacy and safety of lovastatin, new hypolipidemic agent of HMG-CoA reductase inhibitor, we administered lovastatin 40mg to 80mg once daily for 12 weeks in 20 patients(7 males,...
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