Korean J Dermatol.  1999 Apr;37(4):535-537.

Ichthysiform Skin Eruptions Possibly Due to Lovastatin(Mevacor)

• Park JH
• Oh KS
• Lee HJ
• Whang KU

Abstract

Lovastatin(Mevacor) belongs to a new generation of potent drugs for the treatment of hypercho- lesterolemia. It acts by competitive inhibition of 3-hydroxyl-3-methylglutaryl coenzyme A(HMG-CoA) reductase, diminishing in that way the cholesterol synthesis in the liver. HMG-CoA reductase inhibitors also affect cutaneous lipid content. This can induce cutaneous side effects such as eczernatous rashes or xerotic, ichthyosiform lesions due to abnormality in the barrier function in some patients. We report a 54-year-old male patient who developed ichthyosiform skin lesions under treatment with lovastatin(Mevacor) for hypercholesterolemia.

Keyword

Ichthyosiform skin lesion; Lovastatin

MeSH Terms

Cholesterol
Exanthema
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Liver
Lovastatin
Male
Middle Aged
Oxidoreductases
Skin*
Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lovastatin
Oxidoreductases