Korean Circ J.  1991 Apr;21(2):328-336. 10.4070/kcj.1991.21.2.328.

The Effect of Lovastatin(Mevacor(R)) in Patients with Hypercholesterolemia

Abstract

Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied the therapeutic effect and safety of lovastatin in 18 patients with nonfamilial primary hypercholesterolemia. Patients received 20mg/day lovastatin therapy as a single evening dose. If the total cholesterol level exceeded 200mg/dl after 2weeks of lovastatin therapy, the dosage of lovastatin was doubled. Mean percent total cholesterol level reductions from baseline were 26.4% and 31.9% after 4, and 8 weeks of lovastatin therapy respectively. Mean percent HDL-cholesterol level increase from baseline were 12% and 13% after 4, and 8 weeks of lovastatin therapy respectively. Adverse effects attributable to lovastatin were mild and temporary and no patient was withdrawn from therapy. We concluded that lovastatin was a well tolerated and effective agent for the treatment of nonfamilial primary hypercholesterolemia. Further studies are needed to establish the long-term safety and effectiveness of this drug.

Keyword

Hypercholesterolemia; Lovastatin

MeSH Terms

Cholesterol
Coenzyme A
Humans
Hypercholesterolemia*
Lovastatin
Mevalonic Acid
Oxidoreductases
Cholesterol
Coenzyme A
Lovastatin
Mevalonic Acid
Oxidoreductases
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