Korean Circ J.  1991 Aug;21(4):781-785. 10.4070/kcj.1991.21.4.781.

Effects of Lovastatin(Mevacor(R)) on Lowering Plasma Lipids in Patients with Hyperlipidemia

• Lee HJ
• Min CH
• Choi KS
• Ryu WS
• Ryoo UH

• KMID: 2229169
• DOI: http://doi.org/10.4070/kcj.1991.21.4.781

Abstract

Lovastatin, a competitive inhibitor of the rate limiting enzyme in cholesterol biosynthesis was administered to 34 patients with primary hypertlipidemia, 20 mg once daily with the evening meal. Patients experienced mean total and LDL cholesterol reductions of 30.9% and 34.0% respectively. HDL cholesterol level was significantly increased by 15.4% and plasma triglyceride level was decreased by 11.2%. maximal hypocholesterolemic effects were evident at 8 weeks, after which the effects were stable. Adverse effects were noted in 2 patients who had mild gastrointestinal symptoms, that subsided after discontinuing the drug. We concluded that lovastatin is a well tolerated and effective agent for the treatment of primary hyperlipidemia.

Keyword

Hypertlipidemia; Lovastatin

MeSH Terms

Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Humans
Hyperlipidemias*
Lovastatin
Meals
Plasma*
Triglycerides
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Lovastatin