J Korean Soc Transplant.
2001 Dec;15(2):246-250.
Three Cases of Lovastatin Induced Rhabdomyolysis Following Renal Transplantation
- Affiliations
-
- 1Department of Internal Medicine, Kyung Hee University Medical College, Seoul, Korea. kmcim@chollian.net
Abstract
- In renal transplantation, cardiovascular disease is a frequent cause of mortality and morbidity. Post-transplant lipoprotein abnormalities may contribute to the development of cardiovascular disease and chronic renal allograft rejection. Post- transplant hyperlipidemia is commonly related to immunosuppressive therapy. Lovastatin effectively lowers cholesterol in patients after renal transplantation and may be of potential benefit in preventing graft atherosclerosis with a few side effects. But the drug can cause severe complication. Rhabdomyolysis is one of the complications, which can cause acute renal failure. In Korea, lovastatin use after renal transplantation is common, but rhabdomyolysis is rarely reported. So, we report three cases of rhabdomyolysis. Physicians should be aware of the dose of lovastatin and potential risks of combined therapy with cyclosporin in renal transplant patients.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Rhabdomyolysis in a Cyclosporine-treated Renal Transplant Recipient Who Received Atorvastatin as Replacement for Fluvastatin
- Rhabdomyolysis associated with lovastatin-cyclosporine combination therapy : report of three cases in kidney transplant recipients
- Rhabdomyolysis Induced by Hypothyroidism in a Kidney Transplant Recipient
- The effects of lovastatin on puromycin aminonucleoside-induced focal segmental glomerulosclerosis in rats
- A Case of Acute Renal Failure due to Rhabdomyolysis Induced by Convulsion
