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Clonal Cell Proliferation in Paroxysmal Nocturnal Hemoglobinuria: Evaluation of PIGA Mutations and T-cell Receptor Clonality

Park J, Kim M, Kim Y, Han K, Chung NG, Cho B, Lee SE, Lee JW

BACKGROUND: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired pluripotent hematopoietic stem cell disorder associated with an increase in the number of glycosyl-phosphatidyl inositol (GPI)-deficient blood cells. We investigated PNH clonal...
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T-Cell Receptor Rearrangements Determined Using Fragment Analysis in Patients With T-Acute Lymphoblastic Leukemia

Kim H, Kim IS, Chang CL, Kong SY, Lim YT, Kong SG, Cho EH, Lee EY, Shin HJ, Park HJ, Eom HS, Lee H

BACKGROUND: Chromosomal abnormalities and common genetic rearrangements related to T-acute lymphoblastic leukemia (T-ALL) are not clear. We investigated T-cell receptor (TCR) rearrangement in Korean T-ALL patients by fragment analysis, examining...
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Poikiloderma Vasculare Atrophicans Showing Features of Ashy Dermatosis in the Beginning

Jeon J, Kim JH, Ahn JW, Song HJ

Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic...
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Intravascular Cytotoxic T-Cell Lymphoma in a Young Immunocompetent Woman

Jang YH, Lee SJ, Choi YH, Lee WJ, Kim DW, Kim J, Park TI, Chae YS

Intravascular lymphoma (IVL) is a rare disorder characterized by the presence of large neoplastic lymphoid cells restricted to the lumens of small vessels with a predilection for the skin and...
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Alteration of NOTCH1 in T-cell Acute Lymphoblastic Leukemia and Development of Target Therapeutic Agent

Rho JH, Jeon IS

  • KMID: 2279833
  • Clin Pediatr Hematol Oncol.
  • 2014 Apr;21(1):1-8.
T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 10-15% of entire ALL in children. The outcome of T-ALL has been improved through the intensified therapeutic strategy, however, it is still...
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Nodular lymphoid hyperplasia of the stomach in a patient with multiple submucosal tumors

Jeon JY, Lim SG, Kim JH, Lee KM, Cho SR, Han JH

Nodular lymphoid hyperplasia of the stomach is a rare lymphoproliferative disorder. Here, we report a 38-year-old man who presented with multiple submucosal tumors of the stomach. Histologically, the lesions were...
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EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood

Hong M, Ko YH, Yoo KH, Koo HH, Kim SJ, Kim WS, Park H

  • KMID: 2277458
  • Korean J Pathol.
  • 2013 Apr;47(2):137-147.
BACKGROUND: Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH), EBV-positive systemic T-cell lymphoproliferative disease (STLPD) of childhood, and chronic active EBV (CAEBV) infection may develop after primary EBV infection. This study reviewed...
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CD20 Positive T Cell Lymphoma Involvement of Skin

Lee KY, Jeon SY, Hong JW, Kim YH, Song KH, Kim KH

  • KMID: 2383261
  • Ann Dermatol.
  • 2011 Nov;23(4):529-535.
CD20 positive T cell lymphoma is a rare condition that is associated with the coexpressions of CD20 and T cell markers, such as, CD3, CD5, or UCHL-1. Positivity for CD20...
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Gene Expression Profile of T-cell Receptors in the Synovium, Peripheral Blood, and Thymus during the Initial Phase of Collagen-induced Arthritis

Kim JY, Lim MK, Sheen DH, Kim C, Lee SY, Park H, Lee MJ, Lee SK, Yang YS, Shim SC

BACKGROUND: Current management strategies attempt to diagnose rheumatoid arthritis (RA) at an early stage. Transcription profiling is applied in the search for biomarkers for detecting early-stage disease. Even though gene...
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Lymphomatoid Papulosis Followed by Anaplastic Large Cell Lymphoma in a Pediatric Patient

Min JA, Oh ST, Kim JE, Cho BK, Chung NG, Park HJ

Lymphomatoid papulosis (LyP) is a benign, self-healing, papular eruption that can wax and wane over time. Transformation to T-cell lymphoma has been well documented in 10% to 20% of adults...
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Angioimmunoblastic T Cell Lymphomas: Frequent Cutaneous Skin Lesions and Absence of Human Herpes Viruses

Yoon GS, Choi YK, Bak H, Kim BJ, Kim MN, Choi J, Rheu HM, Huh J, Choi JH, Chang SE

BACKGROUND: Angioimmunoblastic T-cell lymphoma (AITL) is a complex lymphoproliferative disorder and often mimics a viral infection with frequent skin involvement. Epstein-Barr virus (EBV) and human herpes virus (HHV)-6 are reported...
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The Effects of Intradermal Vaccination with DNA Encoding for the T-cell Receptor on the Induction of Experimental Autoimmune Encephalomyelitis in B10.PL Mice

Kwon SS, Kim N, Yoo TJ

Intradermal gene administration was found to induce a more profound immune response than direct intramusclular gene injection. We performed intradermal vaccination of B10.PL mice with DNA encoding for the V...
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A Case of Subcutaneous Panniculitic T-cell Lymphoma-like Lesion Occurring in a Patient with Systemic Lupus Erythematosus

Kim JW, Kim SS

  • KMID: 1931203
  • Korean J Dermatol.
  • 2005 Sep;43(9):1241-1246.
Subcutaneous panniculitic T-cell lymphoma and lupus panniculitis may present histologic similarities, including lobular lymphocytic infiltrate, eosinophilic fat necrosis, histiocytic cytophagocytosis, lymphocytic angioinvasion and lymphocytic atypia. The observation that lupus panniculitis...
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A Clinical and Histopathological Study of Parapsoriasis

Hwang ES, Kye YC, Kim SN

  • KMID: 2302853
  • Korean J Dermatol.
  • 2004 Aug;42(8):988-996.
BACKGROUND: Parapsoriasis described a group of cutaneous disease that can be characterized by scaly patches or slightly elevated plaques that have a resemblance to psoriasis, hence the nomenclature. Up to...
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A Case of Kimura's Disease: Approach by Immunohistochemical Study and Analysis of Clonality

Hwang KC, Park JH, Kye YC, Kim SN

  • KMID: 2116101
  • Korean J Dermatol.
  • 2004 Jun;42(6):740-745.
Kimura's disease is a chronic, inflammatory disorder of unknown origin. It is characterized by clinically recurrent painless swelling on head and neck region, histopathologically multiple lymphoid follicles, increased serum IgE...
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A Case of Blastoid NK cell Lymphoma

Choi HJ, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK

  • KMID: 2302923
  • Korean J Dermatol.
  • 2004 Mar;42(3):337-340.
Blastic/blastoid natural killer cell lymphoma is a rare disease characterized by blastic cytological features, lack of cytoplasmic granulues and Epstein-Barr virus (EBV) association, expression of CD56, and the germline TCR...
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A Case of Nasal T/NK-cell Lymphoma

Lee JB, Jeon IS, Im HJ, Oh YH, Kim JH

  • KMID: 2335802
  • J Korean Pediatr Soc.
  • 2003 Dec;46(12):1266-1270.
The advance of the immunobiology clarifies the nature of non-Hodgkin's lymphoma(NHL). In addition the proceed in the immunophenotyping renders the classification of NHL. According to the Revised European American Lymphoma(REAL)...
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T Cell Receptor Rearrangement in NKT Cells Differentiated from Cord Blood CD34+ Cells

Jung YJ, Woo SY

OBJECTIVES: To investigate the time of rearrangement of the TCR gene in the process of NKT cell differentiation from CD34+ human cord blood cells in vitro. METHODS: We isolated the CD34+...
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A Case of Subcutaneous Panniculitic T-cell Lymphoma Involved in Skin and Central Nervous System

Lee EJ, Kim HW, Seo YJ, Lee JH, Suhr KB, Park JK, Kim YC, Cho KH

  • KMID: 2303006
  • Korean J Dermatol.
  • 2003 May;41(5):634-640.
Subcutaneous panniculitic T-cell lymphoma(SPTCL) is categorized as a rare subtype of peripheral T-cell lymphoma. It is characterized by primary involvement of the subcutaneous fat in a manner mimicking panniculitis with/without...
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Diagnostic Utility of Polymerase Chain Reaction-Based Clonality Analysis for Immunoglobulin Heavy Chain Gene and T-cell Receptor Gamma Chain Gene Rearrangement in Lymphoid Neoplasms

Cho EY, Ko YH, Kim DS, Han JJ, Ree HJ

  • KMID: 2275585
  • Korean J Pathol.
  • 2001 Dec;35(6):461-469.
BACKGROUND: The clonality of lymphoid infiltrates determined by polymerase chain reaction (PCR) for immunoglobulin heavy chain (IgH) or T cell receptor (TCR) genes is not only useful in confirming the...
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