Korean J Dermatol.  2005 Sep;43(9):1241-1246.

A Case of Subcutaneous Panniculitic T-cell Lymphoma-like Lesion Occurring in a Patient with Systemic Lupus Erythematosus

• Kim JW
• Kim SS

Abstract

Subcutaneous panniculitic T-cell lymphoma and lupus panniculitis may present histologic similarities, including lobular lymphocytic infiltrate, eosinophilic fat necrosis, histiocytic cytophagocytosis, lymphocytic angioinvasion and lymphocytic atypia. The observation that lupus panniculitis precedes or coincides with subcutaneous panniculitic T-cell lymphoma can make the diagnosis even more enigmatic. We describe a case of a 46-year old woman who presented with multiple infiltrative nodules on her arm. Her medical history of ongoing systemic lupus erythematosus favored a presumptive diagnosis of lupus panniculitis. However, the histopathologic examination, immunohistochemical study and T-cell receptor gene analysis revealed subcutaneous panniculitic T-cell lymphoma with hemophagocytic syndrome.

Keyword

Subcutaneous panniculitic T-cell lymphoma; Systemic lupus erythematosus

MeSH Terms

Arm
Cytophagocytosis
Diagnosis
Eosinophils
Fat Necrosis
Female
Genes, T-Cell Receptor
Humans
Lupus Erythematosus, Systemic*
Lymphohistiocytosis, Hemophagocytic
Lymphoma, T-Cell
Middle Aged
Panniculitis, Lupus Erythematosus
T-Lymphocytes*