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Fumigaclavine C attenuates adipogenesis in 3T3-L1 adipocytes and ameliorates lipid accumulation in high-fat diet-induced obese mice

Yu WG, He Y, Chen YF, Gao XY, Ning WE, Liu CY, Tang TF, Liu Q, Huang XC

Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether...
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Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)

Park M, Lee C, Lee HJ

PURPOSE: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes,...
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Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice

Wang Y, Lee MY, Mak JC, Ip MS

BACKGROUND: The relationship between obstructive sleep apnoea (OSA) and metabolic disorders is complex and highly associated. The impairment of adipogenic capacity in pre-adipocytes may promote adipocyte hypertrophy and increase the...
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The Regulatory Effects of Trans-chalcone on Adipogenesis

Han Y

It is noted that chalcone derivatives have characteristic diverse pharmacological properties, and that precise evidence has been growing that they could regulate a tumor necrosis factor-α (TNF-α) induced insulin resistance....
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Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice

Jo SJ, Kim JW, Choi HO, Kim JH, Kim HJ, Woo SH, Han BH

Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (ICâ‚…â‚€; 2.5...
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Lnk is an important modulator of insulin-like growth factor-1/Akt/peroxisome proliferator-activated receptor-gamma axis during adipogenesis of mesenchymal stem cells

Lee JH, Lee SH, Lee HS, Ji ST, Jung SY, Kim JH, Bae SS, Kwon SM

Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of...
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The Inhibitory Effect of Testosterone on PPARγ-induced Adipogenesis

Jeong S

BACKGROUND: Peroxisome proliferator-activated receptor γ (PPARγ) plays a major role in adipocyte differentiation. Testosterone is well known for inhibiting adipocyte metabolism in men. To investigate the inhibitory mechanism of testosterone...
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miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells

Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ

Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by...
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The micosporine-like amino acids-rich aqueous methanol extract of laver (Porphyra yezoensis) inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes

Kim H, Lee Y, Han T, Choi EM

BACKGROUND/OBJECTIVES: Increased mass of adipose tissue in obese persons is caused by excessive adipogenesis, which is elaborately controlled by an array of transcription factors. Inhibition of adipogenesis by diverse plant-derived...
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Adipogenesis of Sprague Dawely rats mesenchymal stem cells: a morphological, immunophenotyping and gene expression follow-up study

Sobh MA

Mesenchymal stem cells (MSCs) offer significant promise as a multipotent source for cell-based therapies and could form the basis for the differentiation and cultivation of tissue grafts to replace damaged...
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Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocytes

Kim KB, Jang SH

  • KMID: 2327454
  • J Nutr Health.
  • 2014 Feb;47(1):1-11.
PURPOSE: Several studies have proven that EGCG, the primary green tea catechin, and glucosamine-6-phosphate (PGlc) reduce triglyceride contents in 3T3-L1 adipocytes. The objective of this study is to evaluate the...
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Pear pomace water extract inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes

Rhyu J, Kim MS, You MK, Bang MA, Kim HA

  • KMID: 2313708
  • Nutr Res Pract.
  • 2014 Feb;8(1):33-39.
Obesity occurs when a person's calorie intake exceeds the amount of energy burns, which may lead to pathologic growth of adipocytes and the accumulation of fat in the tissues. In...
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Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet

Min B, Lee H, Song JH, Han MJ, Chung J

BACKGROUND/OBJECTIVES: The purpose of this study was to examine the effects and associated mechanisms of arctiin, a lignan compound found in burdock, on adipogenesis in 3T3-L1 cells. Also, the effects...
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Transcriptome analysis and promoter sequence studies on early adipogenesis in 3T3-L1 cells

Kim SJ, Lee KH, Lee YS, Mun EG, Kwon DY, Cha YS

  • KMID: 2313288
  • Nutr Res Pract.
  • 2007 Mar;1(1):19-28.
To identify regulatory molecules which play key roles in the development of obesity, we investigated the transcriptional profiles in 3T3-L1 cells at early stage of differentiation and analyzed the promoter...
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The Effects of Epigallocatechin on Adipogenesis of 3T3-L1 Preadipocytes

Park SG, Kim JS, Kim NG, Park TG, Kim JY

  • KMID: 2119896
  • J Korean Soc Plast Reconstr Surg.
  • 2004 Jan;31(1):83-88.
Preadipocyte cell lines are useful models for investigating adipogenesis process. 3T3-L1 preadipocyte, which can be induced to differentiate into adipocyte in cell culture, is one of the most studied preadipocyte...
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Peroxisome Proliferator-Activated Receptor gammaActivation Promotes Adipogenesis in Human Mesenchymal Stem Cells

Kim EJ, Kim SH, Kim YH, Kim SJ, Hahn SB, Lee JW

  • KMID: 2023943
  • J Korean Orthop Res Soc.
  • 2003 Apr;6(1):127-134.
PURPOSE: In this study, we determined that the troglitazones could induce uniform adipogenesis of human mesenchymal stem cells (MSCs) within a short time in a dose- and a time-dependent manners....
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Effect of High-Dose Steroid Treatment on Adipogenesis and Secretion of PAI-1 in Rats

Song JH, Kim YS

  • KMID: 2199158
  • J Korean Orthop Res Soc.
  • 1999 Oct;2(2):117-124.
This study was conducted to invetigate the effect of high-dose steroid administration on adipogenesis and secretion of PAI-1 in rat. Sixty healthy Wistar rats were divided into three groups. Group...
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Plasticity of Cloned Human Marrow Adipocytes between Osteogenesis and Adipogenesis

Park SR

  • KMID: 2199186
  • J Korean Orthop Res Soc.
  • 1998 Oct;1(2):239-247.
Information on the interconversion potential of adipocytes, the key in the understanding of bone turnover in metabolic diseases such as osteoporosis has been limited by the lack of pure adipocytic...
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