Endocrinol Metab.  2014 Jun;29(2):122-135. 10.3803/EnM.2014.29.2.122.

Regulation of Adipocyte Differentiation via MicroRNAs

Affiliations
  • 1Seoul National University School of Biological Sciences, Seoul National University, Seoul, Korea. jaebkim@snu.ac.kr
  • 2Institute of Molecular Biology and Genetics, Seoul National University, Seoul, Korea.

Abstract

Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors, hormones and signaling pathway molecules. Recent studies have demonstrated that microRNAs, which belong to small noncoding RNA species, are also involved in adipocyte differentiation. In vivo and in vitro studies have revealed that various microRNAs affect adipogenesis by targeting several adipogenic transcription factors and key signaling molecules. In this review, we will summarize the roles of microRNAs in adipogenesis and their target genes associated with each stage of adipocyte differentiation.

Keyword

MicroRNAs; Adipocyte differentiation; Obesity
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