Korean J Ophthalmol.  2006 Sep;20(3):162-165. 10.3341/kjo.2006.20.3.162.

Transforming Growth Factor-beta Levels in Human Aqueous Humor of Glaucomatous, Diabetic and Uveitic Eyes

Affiliations
  • 1Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea. eye1001@paran.com
  • 2Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Pyeongchon, Korea.

Abstract

PURPOSE: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma. METHODS: The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method. RESULTS: The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG. CONCLUSIONS: These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

Keyword

Aqueous humor; Neovascular glaucoma; Primary open angle glaucoma; Secondary open angle glaucoma; Transforming growth factor-beta

MeSH Terms

Uveitis/*metabolism
Transforming Growth Factor beta/*metabolism
Severity of Illness Index
Middle Aged
Humans
Glaucoma, Open-Angle/*metabolism
Glaucoma, Angle-Closure/*metabolism
Enzyme-Linked Immunosorbent Assay
Diabetic Retinopathy/*metabolism
Biological Markers/metabolism
Aqueous Humor/*metabolism
Aged, 80 and over
Aged
Adult

Figure

  • Fig. 1 Concentration of total transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.

  • Fig. 2 Concentration of active transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.


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