Korean J Ophthalmol.  2007 Jun;21(2):90-94. 10.3341/kjo.2007.21.2.90.

Analysis of Aqueous Humor Calcium and Phosphate from Cataract Eyes with and without Diabetes Mellitus

• Kim CJ
• Choi SK

• KMID: 1101910
• DOI: http://doi.org/10.3341/kjo.2007.21.2.90

Abstract

PURPOSE: To compare the levels of calcium and phosphorus in the aqueous humor and serum of diabetics and non-diabetics. METHODS: We divided patients into two groups: seventy-six non-diabetic cataract patients and fifty-two diabetic cataract patients. The diabetic group was divided again into three subgroups: twenty-six patients with no diabetic retinopathy, thirteen patients with non-proliferative diabetic retinopathy, and thirteen patients with proliferative diabetic retinopathy. The authors compared the levels of calcium and phosphorus in the serum and aqueous humor of cataract patients. Statistic analysis was performed to form two comparisons: 1) a comparison between non-diabetics and diabetics and 2) a comparison among non-diabetics and the three subgroups of diabetics. RESULTS: In serum, calcium levels did not statistically differ between non-diabetics and diabetics. The phosphorus level was also not significantly different. In the aqueous humor, however, while calcium levels did not differ significantly, the phosphorus levels in diabetics were considerably higher than those in non-diabetics. When non-diabetics were compared to the three diabetic subgroups, calcium levels did not differ in serum or aqueous humor, but the phosphorus levels in diabetics with proliferative diabetic retinopathy were significantly higher than those in non-diabetics, diabetics without diabetic retinopathy, and diabetics with non-proliferative diabetic retinopathy. CONCLUSIONS: The level of phosphorus in the aqueous humor and serum of diabetics was significantly increased, especially in diabetics with proliferative diabetic retinopathy. This result may be related to hydrophilic acrylic IOL opacification. Future studies regarding the pathogenic role of a high concentration of aqueous humor and serum phosphorus are required.

Keyword

Aqueous humor; Calcium; Cataract; Diabetic retinopathy; Phosphate

MeSH Terms

Aged
Aged, 80 and over
Aqueous Humor/*chemistry
Biological Markers/analysis
Calcium/*analysis
Cataract/complications/*metabolism
Diabetic Retinopathy/complications/*metabolism
Female
Humans
Male
Middle Aged
Phosphorus/*analysis
Regression Analysis
Retrospective Studies

Figure

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  Fig. 1 Boxplot of the concentration of phosphorus in the aqueous humor.

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  Fig. 2 Boxplot of the concentration of phosphorus in serum.

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  Fig. 3 regression analysis of the concentration of phosphorus in the aqueous humor with respect to the concentration of phosphorus in serum.

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