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MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma

Zhu H, Luo H, Zuo X

  • KMID: 2154260
  • Exp Mol Med.
  • 2013 Sep;45(9):e41.
miRNAs are important post-transcriptional regulators. The aberrant expression of miRNAs is strongly associated with the initiation and progression of pathophysiologic processes in a wide range of human diseases. Scleroderma (systemic...
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Influence of Infliximab on Cytokines Network and Markers of Bone Remodeling in Rheumatoid Arthritis Patients

Korczowska I, Lacki JK, Hrycaj P

PURPOSE: Our aim was to determine the effects of infliximab on bone mineral metabolism in rheumatoid arthritis (RA) patients and analyze the relationship between inflammatory markers of acute phase thought...
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Immunohistochemical evaluation of the goat forestomach during prenatal development

Garcia A, Masot J, Franco A, Gazquez A, Redondo E

Here we report the detection and distribution of synaptophysin (SPY), non-neuronal enolase (NNE), glial fibrillary acidic protein (GFAP), vimentin (VIM), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) expression in...
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Ozone Exposure Suppresses Proliferative Response in Mice Skin

Han SJ, Kwak MK, Han DH, Kim SH, Jang AS

No abstract available.
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Oxidative Stress in Vivax Malaria

Bilgin R, Yalcin MS, Yucebilgic G, Koltas IS, Yazar S

  • KMID: 1792135
  • Korean J Parasitol.
  • 2012 Dec;50(4):375-377.
Malaria is still a leading cause of morbidity and mortality. The increase in lipid peroxidation reported in malaria infection and antioxidant status may be a useful marker of oxidative stress...
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The Difference of Lymphocyte Subsets Including Regulatory T-Cells in Umbilical Cord Blood between AGA Neonates and SGA Neonates

Yoon SH, Hur M, Hwang HS, Kwon HS, Sohn IS

PURPOSE: This study aimed to compare the regulatory T cells in cord blood of appropriate for gestational age (AGA) neonates with those of small for gestational age (SGA) neonates. MATERIALS AND...
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Role of placenta growth factor in cancer and inflammation

Kim KJ, Cho CS, Kim WU

Accumulating evidences have documented that angiogenesis is closely linked to inflammation and regulators of angiogenesis play key roles in various inflammatory conditions. PlGF is an angiogenic protein belonging to the...
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Alterations of proliferative and differentiation potentials of human embryonic stem cells during long-term culture

Park YB, Kim YY, Oh SK, Chung SG, Ku SY, Kim SH, Choi YM, Moon SY

Human embryonic stem cells (hESCs) are considered to be able to stably maintain their characteristics in vitro for prolonged periods, but we had previously encountered changes in proliferative ability and...
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Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

Kim J, Hwang JY, Kim KN, Choi YJ, Chang N, Huh KB

PURPOSE: This study was conducted to determine the association between intake of milk and dairy products as well as calcium and biomarkers related to lipid metabolism in Korean female patients...
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Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions

Kwon MJ, Chung HS, Yoon CS, Lee EJ, Kim TK, Lee SH, Ko KS, Rhee BD, Kim MK, Park JH

BACKGROUND/AIMS: beta-Cell apoptosis caused by increased endoplasmic reticulum (ER) stress is an important pathogenic component of type 2 diabetes mellitus. In theory, sulfonylureas, used for the treatment of diabetes, can...
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Novel Combination Markers for Predicting Survival in Patients with Muscle Invasive Bladder Cancer: USP18 and DGCR2

Kim YH, Kim WT, Jeong P, Ha YS, Kang HW, Yun SJ, Moon SK, Choi YH, Kim IY, Kim WJ

We performed gene expression profiling in bladder cancer patients to identify cancer-specific survival-related genes in muscle invasive bladder cancer (MIBC) patients. Sixty-two patients with MIBC were selected as the original...
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Are Clinical, Laboratory, and Imaging Markers Suitable Predictors of Vesicoureteral Reflux in Children With Their First Febrile Urinary Tract Infection?

Mahyar A, Ayazi P, Mavadati S, Oveisi S, Habibi M, Esmaeily S

PURPOSE: This study was conducted to determine the predictive value of clinical, laboratory, and imaging variables for the diagnosis of vesicoureteral reflux in children with their first febrile urinary tract...
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Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions

Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW

  • KMID: 2154225
  • Exp Mol Med.
  • 2013 Jan;45(1):e6.
Many studies have reported that an electromagnetic field can promote osteogenic differentiation of mesenchymal stem cells. However, experimental results have differed depending on the experimental and environmental conditions. Optimization of...
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A simplified one-step nuclear transfer procedure alters the gene expression patterns and developmental potential of cloned porcine embryos

Park SK, Roh S, Park JI

Various somatic cell nuclear transfer (SCNT) techniques for mammalian species have been developed to adjust species-specific procedures to oocyte-associated differences among species. Species-specific SCNT protocols may result in different expression...
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TGF-beta Mediated Epithelial-Mesenchymal Transition in Autosomal Dominant Polycystic Kidney Disease

Chea SW, Lee KB

PURPOSE: Recent studies have showed that epithelial-mesenchymal transition (EMT) is a key process of glomerular and tubulointerstitial pathology in many chronic kidney diseases. However, there are no data of EMT...
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Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model

Uh ST, Koo SM, Jang AS, Park SW, Choi JS, Kim YH, Park CS

BACKGROUND/AIMS: Acute exacerbations in chronic obstructive pulmonary disease may be related to air pollution, of which ozone is an important constituent. In this study, we investigated the protein profiles associated...
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Increased sFlt-1 to PlGF Ratio in Women Who Subsequently Develop Preeclampsia

Kim SY, Ryu HM, Yang JH, Kim MY, Han JY, Kim JO, Chung JH, Park SY, Lee MH, Kim DJ

The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the...
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Spinal Cord Injury Markedly Altered Protein Expression Patterns in the Affected Rat Urinary Bladder during Healing Stages

Lee JY, Kim BJ, Sim G, Kim GT, Kang D, Jung JH, Hwa JS, Kwak YJ, Choi YJ, Park YS, Han J, Lee CS, Kang KR

The influence of spinal cord injury (SCI) on protein expression in the rat urinary bladder was assessed by proteomic analysis at different time intervals post-injury. After contusion SCI between T9...
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Transforming Growth Factor-beta Levels in Human Aqueous Humor of Glaucomatous, Diabetic and Uveitic Eyes

Min SH, Lee TI, Chung YS, Kim HK

PURPOSE: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in...
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Determination of Appropriate Sampling Time for Job Stress Assessment: the Salivary Chromogranin A and Cortisol in Adult Females

Hong RH, Yang YJ, Kim SY, Lee WY, Hong YP

OBJECTIVES: This study was conducted to determine the appropriate sampling time of the salivary stress markers, chromogranin A (CgA) and cortisol as objective indices of job stress assessment in adult...
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