Yonsei Med J.  1969 Jun;10(1):19-24. 10.3349/ymj.1969.10.1.19.

Effect of Long-Term Administration of Secretory Suppressives on Rat Pancreas (1)

Affiliations
  • 1Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Atropine (2.5 mg/kg), hexamethonium (1 mg/kg), Trasylol (1,000 u/kg), acetazolamide (100 mg/kg), cortisone (5 mg /kg) or procaine (5 mg/kg) were injected intraperitoneally once a day for 21 days into rats (both sexes) fed a low protein diet. The rats were fasted and sacrificed 24 hr after the last injection. Atropine and cortisone, but not the other agents, cause a significant increase in both pancreatic weight and enzymes. Serum amylase increased markedly in the cortisone group and serum GOT and GPT increased but slightly in the atropine group. Enlargement of the pancreatic acini, cellular hypertrophy and increases of zymogen granules were observed in all the groups except the procaine and normal control group. The hypertrophy of acini was more prominent in the atropine and cortisone groups. None of drugs used could induce decrease or depress the enzyme formation and weight of pancreas. This data indicates that long-term administration of these drugs, particularly atropine, cortisone or even other Ragents may induce preferential formation of pancreatic enzymes to exocrine secretions and consequently may cause enlargement of the pancreatic acini.


MeSH Terms

Acetazolamide/administration & dosage*
Alanine Transaminase/blood
Amylases/blood
Animal
Aprotinin/administration & dosage*
Aspartate Aminotransferases/blood
Atropine/administration & dosage*
Cortisone/administration & dosage*
Female
Hexamethonium Compounds*
Lipase/blood
Male
Organ Weight
Pancreas/drug effects*
Pancreas/enzymology
Procaine/administration & dosage*
Rats
Time Factors
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