Clin Exp Otorhinolaryngol.  2019 Nov;12(4):412-419. 10.21053/ceo.2018.01774.

Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 2Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.
  • 3Graduate School of Public Health, Seoul National University, Seoul, Korea.
  • 4Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 5Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, Korea.


To evaluate the relationship among smoking, alcohol consumption, and obesity and benign or malignant parotid tumors in a Korean population.
The Korean National Health Insurance Service-Health Screening Cohort (for ≥40-year-olds) was assessed from 2002 to 2013. In total, 336 benign parotid tumors and 46 malignant parotid tumors were matched with controls at a ratio of 1 to 4 with respect to age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of smoking, alcohol consumption, and obesity. By unconditional logistic regression analyses, the crude and adjusted odds ratios (ORs) were investigated and the 95% confidence intervals (CIs) were counted.
The estimated annual incidence of the benign parotid tumors was 5.66 per 100,000, and that of the malignant parotid tumor was 0.81 per 100,000. The adjusted ORs of smoking for the benign parotid tumors was 2.52 (95% CI, 1.84 to 3.46). This finding was consistent in the subgroups of <60 years old, ≥60 years old, and men. The adjusted ORs of alcohol consumption for the benign parotid tumors showed the statistical significance only in women (adjusted OR, 2.35; 95% CI, 1.10 to 5.00). Obesity did not reach a statistical significance in any analysis.
Benign parotid tumor was related with smoking, and it was linked with alcohol consumption in women only.


Tobacco; Smoking; Alcohol; Ethanol; Parotid; Salivary Gland

MeSH Terms

Alcohol Drinking*
Case-Control Studies*
Cohort Studies*
Logistic Models
Mass Screening*
National Health Programs
Odds Ratio
Salivary Glands


  • Fig. 1. Schematic illustration of the participant selection process used in the present study. Of a total of 514,866 participants, 336 benign parotid tumor patients were matched with 1,344 control I participants (A), and 46 malignant parotid tumor patient were also matched with 184 control II participants (B) based on age, sex, income, region of residence, and past medical history.

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