Korean J Anesthesiol.  2019 Apr;72(2):135-137. 10.4097/kja.d.18.00122.

Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. shdo@snu.ac.kr
  • 2Department of Thoracic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

BACKGROUND
Cholesterol plays an important role in the action of opioid analgesics, but its association with postoperative pain has not been clarified. Our study examined the association of pre- and postoperative total serum cholesterol (TSC), and change between the pre- and postoperative TSC levels with postoperative pain outcomes in patients with non-small cell lung cancer (NSCLC) who underwent video-assisted thoracoscopic surgery (VATS) lobectomy.
METHODS
We retrospectively reviewed medical records of patients with NSCLC who underwent VATS lobectomy at the Seoul National University Bundang Hospital in South Korea. We sought to determine the association between preoperative TSC, TSC on postoperative day (POD) 0-1, and pre- and postoperative changes in TSC by comparing numeric rating scale (NRS) scores on POD 0, 1, and 2 and total morphine equivalent consumption on POD 0-2. Multivariate linear regression analyses were used, and P < 0.05 was considered statistically significant.
RESULTS
A total of 1,720 patients with NSCLC who underwent VATS lobectomy were included in the analysis. The change in TSC, preoperative TSC, and postoperative TSC showed no associations with morphine equivalent consumption on POD 0-2 (P > 0.05). In addition, the changes in TSC, preoperative TSC, and postoperative TSC were not associated with postoperative NRS pain score on POD 0, 1, and 2 (P > 0.05).
CONCLUSIONS
Our results indicated that no significant association was observed between pre- and postoperative TSC level and postoperative pain outcome after VATS lobectomy of the lung.

Keyword

Analgesics; Anesthesia; Cholesterol; Opioid; Pain; Postoperative; Thoracic surgery; Video-assisted

MeSH Terms

Analgesia*
Analgesics
Analgesics, Opioid
Anesthesia
Carcinoma, Non-Small-Cell Lung
Cholesterol*
Humans
Korea
Linear Models
Lung
Medical Records
Morphine
Pain, Postoperative
Retrospective Studies
Seoul
Thoracic Surgery
Thoracic Surgery, Video-Assisted*
Analgesics
Analgesics, Opioid
Cholesterol
Morphine
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