Korean J Urol Oncol.  2018 Apr;16(1):1-6. 10.22465/kjuo.2018.16.1.1.

The Role of MicroRNAs in Oncogenesis and Progression of Prostate Cancer

Affiliations
  • 1Department of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea. sjyun@chungbuk.ac.kr, wjkim@chungbuk.ac.kr

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that target mRNA to reduce gene and protein expression by repressing their targets' translation or inducing mRNA degradation. They play fundamental roles in various cancers, including prostate cancer. Each single miRNA may regulate hundreds of genes, and a certain gene may serve as a target by multiple miRNAs. Hence, miRNAs modulate, cell cycle, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis, etc. In this review, we will summarize the several miRNAs that may function as oncogenes and tumor suppressors. And we will describe the each miRNAs associated with cell cycle, apoptosis, EMT, and metastasis in prostate cancer.

Keyword

Prostatic neoplasms; MicroRNAs; Carcinogenesis

MeSH Terms

Apoptosis
Carcinogenesis*
Cell Cycle
Epithelial-Mesenchymal Transition
MicroRNAs*
Neoplasm Metastasis
Oncogenes
Prostate*
Prostatic Neoplasms*
RNA Stability
RNA, Messenger
RNA, Small Untranslated
MicroRNAs
RNA, Messenger
RNA, Small Untranslated
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