Immune Netw.  2019 Feb;19(1):e4. 10.4110/in.2019.19.e4.

Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Affiliations
  • 1Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
  • 2Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Keimyung University College of Medicine, Daegu 41931, Korea. okjimin@hanmail.net

Abstract

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term "noncoding", lncRNAs have been reported to be involved in gene expression. Accumulating evidence suggests that lncRNAs play crucial roles in the regulation of immune system and the development of autoimmunity. lncRNAs are expressed in various immune cells including T lymphocytes, B lymphocytes, macrophages, neutrophils, dendritic cells, and NK cells, and are also involved in the differentiation and activation of these immune cells. Here, we review recent studies on the role of lncRNAs in immune regulation and the differential expression of lncRNAs in various autoimmune diseases.

Keyword

RNA, long noncoding; Immune system; Autoimmunity; Autoimmune diseases

MeSH Terms

Autoimmune Diseases*
Autoimmunity
B-Lymphocytes
Clinical Coding
Dendritic Cells
Gene Expression
Immune System
Killer Cells, Natural
Macrophages
Neutrophils
Nucleotides
RNA
RNA, Long Noncoding*
T-Lymphocytes
Nucleotides
RNA
RNA, Long Noncoding
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