Exp Mol Med.
2018 Jan;50(1):e428. 10.1038/emm.2017.223.
Critical effects of long non-coding RNA on fibrosis diseases
- Affiliations
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- 1Department of Dermatology, 105th Hospital of PLA, Hefei, China. tangjun0212@163.com
- 2Department of Pathophysiology and High Altitude Pathology, Third Military Medical University, Chongqing, China. nibing@tmmu.edu.cn
- 3Graduate School, Bengbu Medical College, Bengbu, China.
- 4Department of Clinical Laboratory, 150th Hospital of PLA, Luoyang, China.
- 5Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, China.
- 6Institute of Immunology, PLA, Third Military Medical University, Chongqing, China. tangjun0212@163.com
- KMID: 2438358
- DOI: http://doi.org/10.1038/emm.2017.223
Abstract
- The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
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