Biomol Ther.  2018 May;26(3):268-273. 10.4062/biomolther.2017.083.

Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression

Affiliations
  • 1Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea. skoh@ewha.ac.kr
  • 2Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon 28126, Republic of Korea.
  • 3Ingredia SA, 51 Av. Lobbedez, 62033 Arras Cedex, France.
  • 4Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Abstract

Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been shown to possess stress relieving and sleep promoting effects. However, the differential effects of α(S1)-CH on electroencephalographic wave patterns and its effects on the protein levels of γ-aminobutyric acid A (GABA(A)) receptor subtypes in hypothalamic neurons are not well understood. We found α(S1)-CH (120, 240 mg/kg) increased sleep duration in mice and reduced sleep-wake cycle numbers in rats. While α(S1)-CH (300 mg/kg) increased total sleeping time in rats, it significantly decreased wakefulness. In addition, electroencephalographic theta (θ) power densities were increased whereas alpha (α) power densities were decreased by α(S1)-CH (300 mg/kg) during sleep-wake cycles. Furthermore, protein expressions of GABA(A) receptor β1 subtypes were elevated in rat hypothalamus by α(S1)-CH. These results suggest α(S1)-CH, through GABA(A) receptor modulation, might be useful for treating sleep disorders.

Keyword

Sleep; α(S1)-CH; Electroencephalogram; GABA(A) receptor

MeSH Terms

Animals
Caseins*
Electroencephalography
Hypothalamus
Mental Health
Mice
Neurodegenerative Diseases
Neurons
Rats
Receptors, GABA-A*
Sleep Wake Disorders
Wakefulness
Caseins
Receptors, GABA-A
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