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Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS

Leem YH, Park JS, Park JE, Kim DY, Kim HS

Microglial priming is the process of microglial proliferation and activation in response to neurodegeneration and abnormal protein accumulation. Priming makes microglia susceptible to secondary inflammatory stimuli and causes exaggerated inflammatory...
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Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice

Leem YH, Yoon SS, Jo SA

Previous studies have shown disrupted synaptic plasticity and neural activity in depression. Such alteration is strongly associated with disrupted synaptic structures. Chronic stress has been known to induce changes in...
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Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways

Park JS, Leem YH, Park JE, Kim DY, Kim HS

Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a...
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Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression

Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S

Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been...
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Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Seo JS, Choi J, Leem YH, Han PL

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within...
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The Effects of Extracellular pH on Proliferation and Differentiation of human Bone Marrow Stem Cells

Leem YH, Nam TS, Kim JH, Lee KS, Lee DH, Yun J, Chang JS

OBJECTIVES: The purpose of this study is to identify whether the change of pH affects the proliferation and the differentiation of human bone marrow stem cells (hBMSCs) and what mechanism...
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Association between Cadmium and Cognitive Function in the Elderly

Kang MY, Cho SH, Leem YH, Kim JH, Bae SH, Hong YC

  • KMID: 2141480
  • Korean J Occup Environ Med.
  • 2011 Sep;23(3):309-316.
OBJECTIVES: We conducted this study to investigate the relationship between the blood concentration of cadmium and cognitive function in elderly Koreans. METHODS: This research is a part of the Korean Elderly...
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Combination chemotherapy with cytosine arabinoside and idarubicin for acute myelogenous leukemia

Shin HC, Jung CW, Lee JH, Lee JA, Yang SH, Leem YH, Park SY, Kim BK, Kim NK

  • KMID: 1688361
  • Korean J Hematol.
  • 1993 Nov;28(2):247-255.
No abstract available.
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