Urogenit Tract Infect.  2018 Aug;13(2):35-39. 10.14777/uti.2018.13.2.35.

Association between an Interleukin 4 Gene Polymorphism, rs2243268, and Urogenital Tuberculosis

Affiliations
  • 1Department of Urology, Ewha Womans University School of Medicine, Seoul, Korea.
  • 2Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 3Department of Urology, Chung-Ang University School of Medicine, Seoul, Korea.
  • 4Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
  • 5Department of Urology, Dong-A University College of Medicine, Busan, Korea.
  • 6Department of Urology, Dankook University Medical College, Cheonan, Korea. multiorigins@yahoo.com

Abstract

PURPOSE
Urogenital tuberculosis (UGT) is rarely reported in developed countries. This study evaluated the genetic susceptibility of Korean patients to UGT.
MATERIALS AND METHODS
A total of 35 UGT patients who were confirmed pathologically, 44 intrapulmonary tuberculosis (IPT) patients who were confirmed radiologically, and 102 controls over a 6 year period were enrolled in this study. The region of rs2243268 in interleukin-4 (IL-4) gene was amplified from whole blood samples, and the DNA sequences were read using the Sanger method.
RESULTS
Twenty women and 15 men were diagnosed with UGT. The occurrence of the CC, AC, and AA genotypes of rs2243268 were 26 (74.3%), 8 (22.9%), and 1 (2.9%), respectively, in UGT; 28 (63.6%), 15 (34.1%), and 1 (2.3%), respectively, in IPT; and 51 (50.0%), 45 (44.1%), and 6 (5.9%), respectively, in the control groups (p=0.115). The bivariate data of CC and AC/AA were 74.3% and 25.7% in UGT, 63.6% and 36.4% in IPT, and 50.0% and 50.0% in the control groups, respectively (p=0.029). The UGT was significantly different from the control group among the three genotypes (p=0.038, Fisher's exact test) and bivariate genotypes (p=0.017, Fisher's exact test). In addition, people carrying the CC genotype had a higher risk of UGT (odds ratios, 2.889; 95% confidence intervals, 1.233–6.770; p=0.015).
CONCLUSIONS
A single nucleotide polymorphism in the IL-4 gene, rs2243268, is associated with the development of clinical tuberculosis. The CC type of rs2243268 increases the risk of UGT significantly compared to the CA/AA type.

Keyword

Urogenital tuberculosis; rs2243268
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