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Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes

Lee J, Jang A, Seo SJ, Myung SC

BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor...
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2019 Novel Coronavirus Disease Outbreak and Molecular Genetic Characteristics of Severe Acute Respiratory Syndrome-Coronavirus-2

Jeong YS

The 2019 novel coronavirus disease (COVID-19) outbreaks that emerged in Wuhan city, Hubei province, have led to a formidable number of confirmed cases that resulted in >5,700 deaths globally, including...
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Epigenetic Changes in Asthma: Role of DNA CpG Methylation

Bae DJ, Jun JA, Chang HS, Park JS, Park CS

For the past three decades, more than a thousand of genetic studies have been performed to find out the genetic variants responsible for the risk of asthma. Until now, all...
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Cytospora elaeagnicola sp. nov. Associated with Narrow-leaved Oleaster Canker Disease in China

Zhang L, Alvarez LV, Bonthond G, Tian C, Fan X

Cytospora is a genus including important phytopathogens causing severe dieback and canker diseases distributed worldwide with a wide host range. However, identification of Cytospora species is difficult since the currently...
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Recharacterization of the Canine Adenovirus Type 1 Vaccine Strain based on the Biological and Molecular Properties

Yang DK, Kim HH, Lee EJ, Yoo JY, Yoon SS, Park J, Kim CH, Kim HR

Canine adenovirus type 1 (CAV-1) infection results in hepatitis in dogs. In this study, we investigated the biologic and genetic characteristics of the CAV-1 vaccine strain (CAV1V) to improve quality...
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Prevalence and Species Spectrum of Pulmonary Nontuberculous Mycobacteria Isolates at a Tertiary Care Center

Joo YS, Kwak NE, Kim GH, Yoon EJ, Jeong SH

BACKGROUND: Pulmonary infection with nontuberculous mycobacteria (NTM) is increasing in South Korea. Since treatment strategy differs by NTM species, accurate identification is necessary. In this study, using Mycobacterium pulmonary isolates...
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Molecular Genetic and Serologic Analysis of the O allele in the Korean Population

Lee JY, Song SA, Oh SH

BACKGROUND: The recent expansion of knowledge about various ABO alleles has led to the need for a comprehensive measure to cover the numerous polymorphisms dispersed in the ABO gene. A...
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Transient expression of hemagglutinin antigen from canine influenza virus H3N2 in Nicotiana benthamiana and Lactuca sativa

Maharjan P, Choe S

PURPOSE: Canine influenza virus (CIV), H3N2, carries potentiality for zoonotic transmission and genetic assortment which raises a concern on possible epidemics, and human threats in future. To manage possible threats,...
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An Norovirus Outbreak at a Local Festival in Chungnam Korea

Lee H, Kim D, Park S, Park J, Nam HS, Choi J, Park J

Noroviruses (NoV) are the major viral pathogen causing epidemic acute gastroenteritis and outbreaks of foodborne and waterborne illness. During the local festival in Chungnam province, group food poisoning occurred outbreak...
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The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells

Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z

The clustered regularly interspaced short palindrome repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is a versatile genome editing tool with high efficiency. A guide sequence of 20 nucleotides (nt) is commonly...
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Molecular Prevalence of Cryptosporidium spp. in Breeding Kennel Dogs

Itoh N, Tanaka H, Iijima Y, Kameshima , Kimura Y

Cryptosporidium is a common intestinal protozoan that can lead to diarrhea in humans and dogs. The predominant species of infection are C. hominis and C. parvum in humans, and C....
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A New Record and Characterization of Asparagus Purple Spot Caused by Stemphylium vesicarium in Korea

Han JH, Shin JH, Fu T, Kim KS

In 2017, small, elliptical, brownish purple spots on spears and ferns of asparagus were found in fields of Gangwon-do. The isolated fungal species was identified as an ascomycete Stemphylium vesicarium...
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Molecular Detection of Coxiella burnetii in Cattle on Ulleung Island, Korea: A Population-based Study with Four Years of Follow Up

Seo MG, Kwon OD, Kwak D

In a population-based study with 4 years of follow up, we evaluated the prevalence of Coxiella burnetii in cattle on Ulleung Island, Korea. In this study, the rates of C....
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Complete Sequence of the Mitochondrial Genome of Spirometra ranarum: Comparison with S. erinaceieuropaei and S. decipiens

Jeon HK, Park H, Lee D, Choe S, Kang Y, Bia MM, Lee SH, Eom KS

This study was undertaken to determine the complete mitochondrial DNA sequence and structure of the mitochondrial genome of Spirometra ranarum, and to compare it with those of S. erinaceieuropaei and...
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Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model

Shin PK, Zoh Y, Choi J, Kim MS, Kim Y, Choi SW

BACKGROUND/OBJECTIVES: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by hTERT and c-MYC, maintains telomeric DNA sequences. Especially, telomerase is...
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Identification and Characterization of Fungi Contaminated in the Built-In Furniture of an Apartment Home

Choi MA, Ahn GR, Kim SH

Fungal contamination of built-in furniture is a frequent problem in Korea when new apartment is built. However, domestic information on the contaminating fungi is very limited. This study was conducted...
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Identification and Characterization of Macrophomina phaseolina Causing Leaf Blight on White Spider Lilies (Crinum asiaticum and Hymenocallis littoralis) in Malaysia

Huda-Shakirah AR, Kee YJ, Hafifi AB, Mohamad Azni NN, Zakaria L, Mohd MH

Crinum asiaticum and Hymenocallis littoralis, commonly known as spider lilies are bulbous perennial and herbaceous plants that widely planted in Malaysia as ornamental. During 2015–2016, symptom of leaf blight was...
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The First Acanthamoeba keratitis Case of Non-Contact Lens Wearer with HIV Infection in Thailand

Tananuvat , Techajongjintana N, Somboon P, Wannasan A

Acanthamoeba keratitis (AK) is a rare sight-threatening corneal infection, often reporting from contact lens wearers. An asymptomatic human immunodeficiency virus (HIV)-infected Thai male without history of contact lens use complained...
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Mitochondrial DNA Sequence Variability of Spirometra Species in Asian Countries

Jeon HK, Eom KS

Mitochondrial DNA sequence variability of Spirometra erinaceieuropaei in GenBank was observed by reinvestigation of mitochondrial cox1 and cytb sequences. The DNA sequences were analyzed in this study, comprising complete DNA...
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Epigenetic profiling to environmental stressors in model and non-model organisms: Ecotoxicology perspective

Chatterjee N, Gim J, Choi J

Epigenetics, potentially heritable changes in genome function that occur without alterations to DNA sequence, is an important but understudied component of ecotoxicology studies. A wide spectrum of environmental challenge, such...
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