Clin Orthop Surg.  2018 Sep;10(3):271-278. 10.4055/cios.2018.10.3.271.

Mesenchymal Stem Cell Therapy for Bone Regeneration

  • 1Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • 2Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center, Seoul, Korea.
  • 3Institute of Medical and Biological Engineering, Seoul National University Medical Research Center, Seoul, Korea.


Mesenchymal stem cells (MSCs) have been used in clinic for approximately 20 years. During this period, various new populations of MSCs have been found or manipulated. However, their characters and relative strength for bone regeneration have not been well known. For a comprehensive understanding of MSCs, we reviewed the literature on the multipotent cells ranging from the definition to the current research progress for bone regeneration. Based on our literature review, bone marrow MSCs have been most widely studied and utilized in clinical settings. Among other populations of MSCs, adipose-derived MSCs and perivascular MSCs might be potential candidates for bone regeneration, whose efficacy and safety still require further investigation.


Stem cells; Osteogenesis; Bone diseases; Review
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