Korean J Bone Metab.  2011 May;18(1):1-8.

Bone Regeneration from Adipose Stem Cells

Affiliations
  • 1Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, South Korea. gunil@duih.org

Abstract

Reconstruction of large bone defect poses a great challenge to an orthopedic surgeon. Recent advancement in stem cell research ushered the treatment of bone defect with tissue-engineered bone into near-possibility. While adipose stem cells (ASCs) are the most available cell sources for tissue regeneration, their low osteogenic potential is a disadvantage. Several strategies have been developed to enhance the osteogenic differentiation of ASCs. In this review, we summarized literatures and our experience on the technology to promote osteogenesis from ASCs.

Keyword

Adipose tissue; Bone regeneration; Mesenchymal stem cell; Osteogenesis
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