J Rhinol.  2008 May;15(1):7-12.

Bone Marrow-Derived Mesenchymal Stem Cells for Regenerative Medicine

  • 1Department of Otolaryngology-Head and Neck Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea. rhico@yonsei.ac.kr


Bone marrow-derived mesenchymal stem cells (BMMSCs) can be differentiated into a variety of cell types, offering promising approaches for stem-cell mediated tissue regeneration. The facial region contains many specific tissues including bone, cartilage, muscle and neurons. Defect or dysfunction of the facial tissues after cancer surgery, trauma, congenital malformations has a huge influence on the patient's life. Therefore functional reconstruction of damaged tissue is highly sought after. BMMSCs are one of the better characterized postnatal stem cell population and most considered for utilization during cell based clinical therapies. The current review describes what is known about BMMMSCs and their capacity for use as regenerative medicine in the area of otolaryngology.


Mesenchymal stem cells; Tissue engineering; Regenerative medicine
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