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Keratinocyte-Like Cells Trans-Differentiated from Human Adipose-Derived Stem Cells, Facilitate Skin Wound Healing in Mice

Kim J, Hasegawa T, Wada A, Maeda Y, Ikeda S

Background: Mesenchymal stem cells (MSCs) have been reported to promote wound healing in both animal models and human studies. Among MSCs, adipose-derived stem cells (ADSCs) can be easily harvested in...
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Research Advances in the Application of Adipose-Derived Stem Cells Derived Exosomes in Cutaneous Wound Healing

Weiliang Z, Lili G

Cutaneous wound healing has always been an intractable medical problem for both clinicians and researchers, with an urgent need for more efficacious methods to achieve optimal outcomes morphologically and functionally....
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Efficacy and safety of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn’s complex fistula: a Phase IV clinical study

Cho YJ, Kwon H, Kwon YJ, Kim KM, Oh SH, Kim DY

Purpose: Autologous adipose tissue-derived stem cells (ASCs) have been proposed for patients with refractory Crohn disease, but research is lacking in pediatric patients. This Phase IV study evaluated the efficacy...
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Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects

Kosonen R, Barua S, Kim JY, Lee JE

Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have...
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Growth and Differentiation of Circulating Stem Cells After Extensive Ex Vivo Expansion

Barbon S, Rajendran S, Bertalot T, Piccione M, Gasparella M, Parnigotto PP, Liddo RD, Conconi MT

BACKGROUND: Stem cell therapy is gaining momentum as an effective treatment strategy for degenerative diseases. Adult stem cells isolated from various sources (i.e., cord blood, bone marrow, adipose tissue) are being...
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Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts

Choi SJ, Park SY, Shin YH, Heo SH, Kim KH, Lee HI, Kim JK

BACKGROUND: Schwann cells (SCs) secrete neurotrophic factors and provide structural support and guidance during axonal regeneration. However, nearby nerves may be damaged to obtain primary SCs, and there is a...
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Vascularized Organoids: A More Complete Model

Yu J

As an emerging research model in vitro, organoids have achieved major progress in recapitulating morphological aspects of organs and personalized precision therapy. Various organoids have been currently constructed in vitro...
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Postresection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2010 World Health Organization classification: single-center experience of 168 patients

Kim M, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Park GC, Hong SM

Purpose: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) has wide histologic diversity. This study investigated the effects of cHCC-CC histology, according to the 2010 World Health Organization (WHO) classification, on patient...
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Carnosol induces the osteogenic differentiation of bone marrowderived mesenchymal stem cells via activating BMP-signaling pathway

Abdallah BM

Carnosol is a phenolic diterpene phytochemical found in rosemary and sage with reported anti-microbial, anti-oxidant, anti-inflammatory, and anti-carcinogenic activities. This study aimed to investigate the effect of carnosol on the...
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Valproic Acid Enhance Reprogramming of Bactrian Camel Cells through Promoting the Expression of Endogenous Gene c-Myc and the Process of Angiogenesis

Li Z, Ge W, Li Y, Zhang Y, Zhao X, Hu J

Background and Objectives: Induced pluripotent stem cells (iPSCs) are usually generated by reprogramming differentiated cells through the introduction of specific transcription factors, but this is a difficult and inefficient process. Valproic...
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Organoids: A New Model for SARS-CoV-2 Translational Research

Yu J

The 2019-novel coronavirus (SARS-CoV-2) pneumonia epidemic is a thorny public health problem faced by health officials and a major cause of concern for health professionals. However, the currently used immortalized...
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Mesenchymal Stem Cell and MicroRNA Therapy of Musculoskeletal Diseases

Chung MJ, Son JY, Park S, Park SS, Hur K, Lee SH, Lee EJ, Park JK, Hong IH, Kim TH, Jeong KS

The therapeutic effects of mesenchymal stem cells (MSCs) in musculoskeletal diseases (MSDs) have been verified in many human and animal studies. Although some tissues contain MSCs, the number of cells...
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Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells

Park JA, Park S, Choi JK, Han MK, Lee Y

Background and Objectives: Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates...
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The Therapeutic Potential of Amniotic Fluid-Derived Stem Cells on Busulfan-Induced Azoospermia in Adult Rats

Ibrahim HF, Safwat SH, Zeitoun TM, El Mulla KF, Medwar AY

BACKGROUND: Busulfan is an alkylating chemotherapeutic agent that is routinely prescribed for leukemic patients to induce myelo-ablation. However, it also results in azoospermia and infertility in cancer survivors. This research...
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Generation of Hepatic Progenitor Cells from the Primary Hepatocytes of Nonhuman Primates Using Small Molecules

Hong DH, Lee C, Kim Y, Bum S, Han SC, Kim SJ, Yang HM, Choi D, Jeong J, Ryu K

BACKGROUND: Since primates have more biological similarities to humans than do other animals, they are a valuable resource in various field of research, including biomedicine, regenerative medicine, and drug discovery....
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Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells

Cho HS, Park SY, Kim SM, Kim WJ, Jung JY

BACKGROUND: Autophagy plays important roles in odontogenic differentiation of dental pulp cells (DPCs) in the developmental stage of tooth bud. Few studies have reported the role of autophagy during reparative...
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Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation

Kaur Virdi J, Pethe P

Tissue-resident stem cells are surrounded by a microenvironment known as ‘stem cell niche’ which is specific for each stem cell type. This niche comprises of cell-intrinsic and -extrinsic factors like...
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Expression of neurotrophic factor genes by human adipose stem cells post-induction by deprenyl

Amiri A, Kashani MHG, Ghorbanian MT

Human adipose stem cells (hASCs) were introduced as appropriate candidate due to advantages like ease of isolation, in vitro expansion and lack of immune response. Deprenyl (Dep) was used to...
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Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective

Winz C, Suh N

Endocrine disruptors, such as bisphenol A (BPA), have become more frequently present in the environment as contaminants, especially in industrialized countries. Long-term effects of these environmental contaminants in humans are...
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Strategies to enhance graft performance in cord blood transplantation

Yoo KH

Umbilical cord blood (CB) serves as one of the alternative donor sources for hematopoietic stem cell transplantation (HSCT) in those patients lacking a matched related donor. However, the relatively high...
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