Ann Dermatol.  2017 Apr;29(2):194-199. 10.5021/ad.2017.29.2.194.

Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid

Affiliations
  • 1Department of Emergency Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 2Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. Kwak65joy@gmail.com
  • 3Department of Plasticsurgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 4Department of Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 5Burn Institute, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
  • 6Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. hyeonekim@gmail.com

Abstract

BACKGROUND
It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients.
OBJECTIVE
This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters.
METHODS
Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the second, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to determine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period.
RESULTS
The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concentration of HSP70 on the first day and the length of the treatment period. No measurable concentration of IL-8 was detected before 5 hours, but the concentration started to increase after 11 hours. The peak value was measured on the fourth day.
CONCLUSION
While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of inflammatory mediators in burn blister fluid.

Keyword

Heat-shock protein 70; Interleukin-8; Partial thickness burn; Partial thickness burn blister; Wounds and injuries

MeSH Terms

Blister*
Burns*
Heat-Shock Proteins*
Hot Temperature*
HSP70 Heat-Shock Proteins*
Humans
Interleukin-8
Wound Healing
Wounds and Injuries
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Interleukin-8
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