- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy
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Cherukula , Park MS, Sontyana A, Mathew AP, Vijayan V, Bae WK, Park IK
- KMID: 2462185
- J Korean Med Sci.
- 2019 Nov;34(44):e272.
- doi: 10.3346/jkms.2019.34.e272
BACKGROUND: Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by the penetration depth of laser light.... -
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- Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
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Park S, Park JA, Jeon JH, Lee Y
- KMID: 2456216
- Biomol Ther.
- 2019 Sep;27(5):423-434.
- doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in... -
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- MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
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Zhang C, Dai J, Fan Y, He X, Wei R
- KMID: 2448356
- Korean J Intern Med.
- 2019 May;34(3):634-642.
- doi: 10.3904/kjim.2016.315
BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples.... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains
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Farahtaj F, Alizadeh L, Gholami A, Tahamtan A, Shirian S, Fazeli M, Nejad AS, Gorji A, Niknam HM, Ghaemi A
- KMID: 2441507
- Osong Public Health Res Perspect.
- 2019 Feb;10(1):6-11.
- doi: 10.24171/j.phrp.2019.10.1.03
OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying... -
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- The Expression of Adipophilin Is Frequently Found in Solid Subtype Adenocarcinoma and Is Associated with Adverse Outcomes in Lung Adenocarcinoma
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Shin SA, Na HY, Choe JY, Chung D, Park M, Oh S, Kim JE
- KMID: 2427517
- J Pathol Transl Med.
- 2018 Nov;52(6):357-362.
- doi: 10.4132/jptm.2018.09.13
BACKGROUND: The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of... -
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- Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
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Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ
- KMID: 2427511
- Biomol Ther.
- 2018 Nov;26(6):576-583.
- doi: 10.4062/biomolther.2017.233
Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular... -
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- Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
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Lee EB, Kim JH, An CW, Kim YJ, Noh YJ, Kim SJ, Kim JE, Shrestha A, Ham HN, Leem JY, Jo HK, Kim DS, Moon KH, Lee JH, Jeong KO, Kim DK
- KMID: 2427510
- Biomol Ther.
- 2018 Nov;26(6):568-575.
- doi: 10.4062/biomolther.2017.215
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The... -
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- Immediate Effects of a Single Exercise on Behavior and Memory in the Early Period of Traumatic Brain Injury in Rats
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Yoon KJ, Kim DY
- KMID: 2429193
- Ann Rehabil Med.
- 2018 Oct;42(5):643-651.
- doi: 10.5535/arm.2018.42.5.643
OBJECTIVE: To evaluate the immediate effect of single exercise on physical performance and memory in the early stage of traumatic brain injury (TBI) in rats. METHODS: Ninety TBI rats were randomly... -
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- S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion
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Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH
- KMID: 2420062
- J Korean Neurosurg Soc.
- 2018 Sep;61(5):548-558.
- doi: 10.3340/jkns.2017.0200
OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently... -
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- Damage-Associated Molecular Patterns in Inflammatory Diseases
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Roh JS, Sohn DH
- KMID: 2419772
- Immune Netw.
- 2018 Aug;18(4):e27.
- doi: 10.4110/in.2018.18.e27
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although... -
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- Identification of determinants that mediate binding between Tembusu virus and the cellular receptor heat shock protein A9
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Zhao D, Liu Q, Huang X, Wang H, Han K, Yang J, Bi K, Liu Y, Zhang L, Li Y
- KMID: 2417568
- J Vet Sci.
- 2018 Jul;19(4):528-535.
- doi: 10.4142/jvs.2018.19.4.528
Heat shock protein A9 (HSPA9), a member of the heat shock protein family, is a putative receptor for Tembusu virus (TMUV). By using Western blot and co-immunoprecipitation assays, E protein... -
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- Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells
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Yun HH, Baek JY, Seo G, Kim YS, Ko JH, Lee JH
- KMID: 2414270
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):457-465.
- doi: 10.4196/kjpp.2018.22.4.457
The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1)... -
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- The Role of Serotonin in Ventricular Repolarization in Pregnant Mice
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Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B
- KMID: 2418792
- Yonsei Med J.
- 2018 Mar;59(2):279-286.
- doi: 10.3349/ymj.2018.59.2.279
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role... -
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- Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27
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Kim YS, Jeong M, Han YM, Park JM, Kwon SO, Hong SP, Hahm KB
- KMID: 2407670
- Korean J Gastroenterol.
- 2018 Mar;71(3):132-142.
- doi: 10.4166/kjg.2018.71.3.132
BACKGROUND/AIMS: Several lines of evidence from epidemiologic and laboratory studies have shown that the consumption of Artemisia or green tea extracts (MPGT) is inversely associated with the risk of alcohol-induced... -
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- The Efficacy and Underlying Mechanism of Moxibustion in Preventing Cognitive Impairment: A Systematic Review of Animal Studies
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Choe S, Cai M, Jerng UM, Lee JH
- KMID: 2405304
- Exp Neurobiol.
- 2018 Feb;27(1):1-15.
- doi: 10.5607/en.2018.27.1.1
Cognitive impairment is age-related and manageable only with early diagnosis and prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive impairment. This systematic review of animal... -
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- Novel non-apoptotic cell death: ferroptosis
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Woo SM, Kwon TK
- KMID: 2400352
- Yeungnam Univ J Med.
- 2017 Dec;34(2):174-181.
- doi: 10.12701/yujm.2017.34.2.174
Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic... -
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- Proteomic Analysis of Human Adipose Derived Stem Cells during Small Molecule Chemical Stimulated Pre-neuronal Differentiation
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Santos J, Milthorpe , Herbert BR, Padula MP
- KMID: 2400874
- Int J Stem Cells.
- 2017 Nov;10(2):193-217.
- doi: 10.15283/ijsc17036
BACKGROUND: Adipose derived stem cells (ADSCs) are acquired from abdominal liposuction yielding a thousand fold more stem cells per millilitre than those from bone marrow. A large research void exists... -
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- Targeting the epitope spreader Pep19 by naïve human CD45RA⺠regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy
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Kim HJ, Cha GS, Joo JY, Lee J, Kim SJ, Lee J, Park SY, Choi J
- KMID: 2392717
- J Periodontal Implant Sci.
- 2017 Oct;47(5):292-311.
- doi: 10.5051/jpis.2017.47.5.292
PURPOSE: Beyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery... -
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