J Bacteriol Virol.  2015 Mar;45(1):62-66. 10.4167/jbv.2015.45.1.62.

Heat Shock Protein 90 (HSP90) and Immune Regulation

Affiliations
  • 1Departments of Microbiology, School of Medicine, Ewha Womans University, Seoul, Korea. soyounwoo@ewha.ac.kr

Abstract

Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses. Therefore, HSP90 inhibitors potentially useful target for the autoimmune disease and chronic inflammatory diseases.

Keyword

Heat shock protein 90 (HSP90); Anti-inflammatory; HSP90 inhibitor; IL-17; Act1
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