Kidney Res Clin Pract.
2015 Jun;34(2):93-97. 10.1016/j.krcp.2015.05.002.
Transforming growth factor-beta receptor 2 gene polymorphisms are associated with end-stage renal disease
- Affiliations
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- 1Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. apple8840@hanmail.net
- 2Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
- 3Division of Nephrology, School of Medicine, Inje University Paik Hospital, Seoul, Korea.
- KMID: 2381523
- DOI: http://doi.org/10.1016/j.krcp.2015.05.002
Abstract
- BACKGROUND
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety of cellular processes. In addition, several recent studies have reported that TGF-beta receptor (TGF-betaR) gene polymorphism is associated with chronic kidney disease. However, the association between end-stage renal disease (ESRD) and the TGF-beta gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the TGF-beta ligands or their receptors may be related to ESRD.
METHODS
We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the TGF-betaR2 and TGF-beta2 genes and ESRD, in 312 patients with ESRD and 258 controls.
RESULTS
Compared with the control participants, the frequencies of the TGF-betaR2 (rs764522*C) and TGF-betaR2 (rs3087465*G) alleles were significantly higher in the patients with ESRD. Genotyping analysis demonstrated that two SNPs in TGF-betaR2 of the four SNPs included in the study were significantly associated with ESRD in the codominant 1 [rs764522, odds ratio (OR)=1.65; rs3087465, OR=1.63], dominant (rs764522, OR=1.63; rs3087465, OR=1.57), and log-additive (rs764522, OR=1.54; rs3087465, OR=1.39) models after adjusting for age and sex.
CONCLUSION
We suggest that TGF-betaR2 polymorphisms (rs764522 and rs3087465) increase the risk of development of ESRD.
MeSH Terms
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Alleles
Asthma
Fibrosis
Humans
Immune System Diseases
Kidney Failure, Chronic*
Ligands
Lung
Odds Ratio
Polymorphism, Single Nucleotide
Receptors, Transforming Growth Factor beta
Renal Insufficiency, Chronic
Signal Transduction
Transforming Growth Factor beta
Transforming Growth Factor beta2
Ligands
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Transforming Growth Factor beta2
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