- Current Status and Future Direction of Immunotherapy in Hepatocellular Carcinoma: What Do the Data Suggest?
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Lee HW, Cho KJ, Park JY
- KMID: 2471051
- Immune Netw.
- 2020 Feb;20(1):e11.
- doi: 10.4110/in.2020.20.e11
Most patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage of disease. Until recently, systemic treatment options that showed survival benefits in HCC have been limited to tyrosine... -
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- Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity
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Lee HW, Chung YS, Kim TJ
- KMID: 2471045
- Immune Netw.
- 2020 Feb;20(1):e5.
- doi: 10.4110/in.2020.20.e5
The γδ T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The γδ T cells can be exploited as... -
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- Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation
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Yoon S, Eom GH
- KMID: 2468140
- Chonnam Med J.
- 2020 Jan;56(1):6-11.
- doi: 10.4068/cmj.2020.56.1.6
Cancer remains a leading cause of death, despite multimodal treatment approaches. Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. Cancer cells... -
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- Scavenger Receptor Class A to E Involved in Various Cancers
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Ryu S, Howland A, Song B, Youn C, Song PI
- KMID: 2468139
- Chonnam Med J.
- 2020 Jan;56(1):1-5.
- doi: 10.4068/cmj.2020.56.1.1
Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such... -
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- Selectins: functional importance as cell adhesion molecule in immune system
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Noh Y, Cho D, Ko H, Lim D, Chai HH
- KMID: 2470310
- J Biomed Transl Res.
- 2019 Dec;20(4):75-81.
- doi: 10.12729/jbtr.2019.20.4.075
Selectins are cell membrane glycoproteins that recognize specific glycoconjugates expressed on the surface of cells. Then, selectins adjust cell-cell interactions that are important in inflammation, hemostasis and cancer metastasis. Selectins... -
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- Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
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Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S
- KMID: 2467417
- Asian Spine J.
- 2019 Dec;13(6):875-889.
- doi: 10.31616/asj.2019.0073
STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against... -
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- The Psychiatric Effects of Cannabis
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Kim BS
- KMID: 2465998
- J Korean Soc Biol Ther Psychiatry.
- 2019 Oct;25(3):183-191.
- doi: 10.0000/jksbtp.2019.25.3.183
With the recent legalization of recreational cannabis in Canada and 11 states of the U.S., the interest surrounding cannabis use is increasing. However, many people and even clinicians in Korea... -
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- Brown Adipocyte and Splenocyte Co-Culture Maintains Regulatory T Cell Subset in Intermittent Hypobaric Conditions
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Kang TH, Park JH, Shin D, Choi H, Kim J, Lee MC
- KMID: 2464073
- Tissue Eng Regen Med.
- 2019 Oct;16(5):539-548.
- doi: 10.1007/s13770-019-00205-y
BACKGROUND: Brown adipocytes have thermogenic characteristics in neonates and elicit anti-inflammatory responses. We postulated that thermogenic brown adipocytes produce distinctive intercellular effects in a hypobaric state. The purpose of this... -
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- Near-Infrared Contrast Agents for Bone-Targeted Imaging
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Jung JS, Jo D, Jo G, Hyun H
- KMID: 2464065
- Tissue Eng Regen Med.
- 2019 Oct;16(5):443-450.
- doi: 10.1007/s13770-019-00208-9
BACKGROUND: For the bone-specific imaging, a structure-inherent targeting of bone tissue recently has been reported a new strategy based on incorporation of targeting moieties into the chemical structure of near-infrared... -
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- Anti-inflammatory Activity of Sambucus Plant Bioactive Compounds against TNF-α and TRAIL as Solution to Overcome Inflammation Associated Diseases: The Insight from Bioinformatics Study
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Putra WE, Ode Salma , Rifa'i M
- KMID: 2459962
- Nat Prod Sci.
- 2019 Sep;25(3):215-221.
- doi: 10.20307/nps.2019.25.3.215
Inflammation is the crucial biological process of immune system which acts as body's defense and protective response against the injuries or infection. However, the systemic inflammation devotes the adverse effects... -
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- Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level
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Pearce LV, Ann J, Blumberg P, Lee J
- KMID: 2456217
- Biomol Ther.
- 2019 Sep;27(5):435-441.
- doi: 10.4062/biomolther.2019.013
The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course... -
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- Extracellular vesicles in renal physiology and clinical applications for renal disease
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Kwon SH
- KMID: 2448338
- Korean J Intern Med.
- 2019 May;34(3):470-479.
- doi: 10.3904/kjim.2019.108
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules.... -
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- Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies
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La MT, Tran VH, Kim HK
- KMID: 2448099
- Nucl Med Mol Imaging.
- 2019 Apr;53(2):115-124.
- doi: 10.1007/s13139-019-00584-z
Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and... -
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- Bacoside A Induced Sub-G0 Arrest and Early Apoptosis in Human Glioblastoma Cell Line U-87 MG through Notch Signaling Pathway
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Aithal MG, Rajeswari
- KMID: 2444792
- Brain Tumor Res Treat.
- 2019 Apr;7(1):25-32.
- doi: 10.14791/btrt.2019.7.e21
BACKGROUND: Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a worst prognosis of less than one year despite advance treatment facilities. Among various signaling pathway genes displaying genetic... -
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- Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
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Choi EO, Hwang HJ, Choi YH
- KMID: 2447436
- J Cancer Prev.
- 2019 Mar;24(1):11-19.
- doi: 10.15430/JCP.2019.24.1.11
BACKGROUND: The roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts... -
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- Isolation of MLL1 Inhibitory RNA Aptamers
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Ul-Haq A, Jin ML, Jeong KW, Kim HM, Chun KH
- KMID: 2442012
- Biomol Ther.
- 2019 Feb;27(2):201-209.
- doi: 10.4062/biomolther.2018.157
Mixed lineage leukemia proteins (MLL) are the key histone lysine methyltransferases that regulate expression of diverse genes. Aberrant activation of MLL promotes leukemia as well as solid tumors in humans,... -
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- Extracellular Vesicles of Neutrophils
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Hong CW
- KMID: 2429835
- Immune Netw.
- 2018 Dec;18(6):e43.
- doi: 10.4110/in.2018.18.e43
Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. As professional phagocytes, neutrophils also produce EVs in response to various inflammatory stimuli during inflammatory processes. Neutrophil-derived EVs can be... -
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- Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
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Yi YS
- KMID: 2429833
- Immune Netw.
- 2018 Dec;18(6):e41.
- doi: 10.4110/in.2018.18.e41
Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein... -
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- miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer
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Yang L, Cai Y, Zhang D, Sun J, Xu C, Zhao W, Jiang W, Pan C
- KMID: 2429815
- J Breast Cancer.
- 2018 Dec;21(4):371-381.
- doi: 10.4048/jbc.2018.21.e60
PURPOSE: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7... -
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- A Case of Aggravation of Thyroid Goiter after Treatment with PD-1 Inhibitor for Breast Cancer in Patients with Underlying Hashimoto's Thyroiditis
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Kim H, Kim MJ, Song YS, Cho SW
- KMID: 2448989
- Int J Thyroidol.
- 2018 Nov;11(2):172-175.
- doi: 10.11106/ijt.2018.11.2.172
Anti-programmed cell death-1 (PD-1) humanized monoclonal antibody inhibits PD-1 activity by binding to the PD-1 receptor on T-cells and blocking PD-1 ligands and induces immune tolerance of cancer cells. It... -
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