Kidney Res Clin Pract.  2015 Mar;34(1):35-40. 10.1016/j.krcp.2015.02.004.

Effect of acute intradialytic strength physical exercise on oxidative stress and inflammatory responses in hemodialysis patients

• Esgalhado
• Stockler-Pinto MB
• Cardozo LF
• Costa C
• Barboza JE
• Mafra D

• KMID: 2381511
• DOI: http://doi.org/10.1016/j.krcp.2015.02.004

Abstract

BACKGROUND
Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly related to the increased risk of developing cardiovascular disease, which is the major cause of death in these patients, particularly for those undergoing hemodialysis (HD). Strength physical exercise is a new therapeutic approach to reduce these complications in CKD patients. Following this, the purpose of this study was to assess the effect of acute intradialytic strength physical exercise on oxidative stress and inflammatory responses in HD patients.
METHODS
Sixteen HD patients were studied (11 women; 44.4+/-14.6 years; body mass index 23.3+/-4.9 kg/m2; 61.6+/-43.1 months of dialysis) and served as their own controls. Acute (single session) intradialytic physical exercise were performed at 60% of the one-repetition maximum test for three sets of 10 repetitions for four exercise categories in both lower limbs during 30 minutes. Blood samples were collected on two different days at exactly the same time (30 minutes and 60 minutes after initiating the dialysis-with and without exercise). Antioxidant enzymes activity [superoxide dismutase (SOD), catalase, and glutathione peroxidase], lipid peroxidation marker levels (malondialdehyde), and inflammatory marker levels (high-sensitivity C-reactive protein) were determined.
RESULTS
SOD plasma levels were significantly reduced after acute physical exercise from 244.8+/-40.7 U/mL to 222.4+/-28.9 U/mL (P=0.03) and, by contrast, increased on the day without exercise (218.2+/-26.5 U/mL to 239.4+/-38.6 U/mL, P=0.02). There was no alteration in plasma catalase, glutathione peroxidase, malondialdehyde, or high-sensitivity C-reactive protein levels in on either day (with or without exercise). Additionally, there was no association between these markers and clinical, anthropometric, or biochemical parameters.
CONCLUSION
These data suggest that acute intradialytic strength physical exercise was unable to reduce oxidative stress and inflammation, and in addition, it seems to reduce plasma SOD levels, which could exacerbate the oxidative stress in HD patients.

Keyword

Chronic kidney disease; Hemodialysis; Acute physical exercise; Inflammatory and oxidative stress markers

MeSH Terms

Body Mass Index
C-Reactive Protein
Cardiovascular Diseases
Catalase
Cause of Death
Exercise*
Female
Glutathione
Glutathione Peroxidase
Humans
Inflammation
Lipid Peroxidation
Lower Extremity
Malondialdehyde
Oxidative Stress*
Plasma
Renal Dialysis*
Renal Insufficiency, Chronic
C-Reactive Protein
Catalase
Glutathione
Glutathione Peroxidase
Malondialdehyde