Ann Lab Med.  2016 Jul;36(4):396-398. 10.3343/alm.2016.36.4.396.

t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia

Affiliations
  • 1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. LEE.ST@yuhs.ac, saeam0304@yuhs.ac
  • 2Department of Pediatrics, Yonsei Cancer Research Center, Yonsei University College of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Base Sequence
Bone Marrow/pathology
Child, Preschool
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 17
Female
Gene Rearrangement
Humans
Karyotype
Oncogene Proteins, Fusion/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics
Sequence Analysis, DNA
TATA-Binding Protein Associated Factors/*genetics
Trans-Activators/*genetics
*Translocation, Genetic
Oncogene Proteins, Fusion
TATA-Binding Protein Associated Factors
Trans-Activators

Figure

  • Fig. 1 (A) G(Giemsa)-T(Trypsin)-G-banding analysis using the bone marrow sample revealed a translocation involving the breakpoint on chromosome 12p13 and 17q11.2. (B) Agarose gel electrophoresis of the TAF15-ZNF384 fusion transcript obtained from patient (approximately 800-bp-sized PCR product) (C) Direct sequencing of complementary DNA showed breakpoints between exon 9 of TAF15 and exon 3 of ZNF384. Lane L, bp markers; Lane Pat, reported patient with TAF15-ZNF384 fusion transcript.


Reference

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