Korean J Crit Care Med.  2017 Feb;32(1):39-46. 10.4266/kjccm.2016.00808.

Comparing the Rates of Dopamine Hemodynamic Effect Onset after Infusion through Peripheral Veins in Three Regions

• Kim D
• Son JS
• Choi WY
• Han YJ
• Lee JR
• Lim H

• KMID: 2371152
• DOI: http://doi.org/10.4266/kjccm.2016.00808

Abstract

BACKGROUND
Dopamine is an inotropic agent that is often selected for continuous infusion. For hemodynamic stability, the rate of infusion is controlled in the range of 5-15 µg/kg/min. This study aimed to compare the time intervals from the administration of dopamine to the onset of its hemodynamic effects when dopamine was administered through three different peripheral veins (the cephalic vein [CV], the great saphenous vein [GSV], and the external jugular vein [EJV]).
METHODS
Patients in group 1, group 2, and group 3 received dopamine infusions in the CV, GSV, and EJV, respectively. A noninvasive continuous cardiac output monitor (NICCOMOâ„¢, Medis, Ilmenau, Germany) was used to assess cardiac output (CO) and systemic vascular resistance (SVR). Six minutes after intubation, baseline heart rate (HR), systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), CO, and SVR values were recorded and dopamine infusion was initiated at a dose of 10 µg/kg/min. Hemodynamic changes at 0, 4, 8, 12, and 15 minutes postinfusion were recorded.
RESULTS
No statistically significant differences were observed among the three groups with respect to the rate of hemodynamic change. In all groups, systolic BP, diastolic BP, MAP, and SVR tended to increase after decreasing for the first 4 minutes; in contrast, HR and CO decreased until 8 minutes, after which they tended to reach a plateau.
CONCLUSIONS
For patients under general anesthesia receiving dopamine at 10 µg/kg/min, there were no clinical differences in the effect of dopamine administered through three different peripheral veins.

Keyword

administration routes; dopamine; hemodynamic status

MeSH Terms

Anesthesia, General
Arterial Pressure
Blood Pressure
Cardiac Output
Dopamine*
Heart Rate
Hemodynamics*
Humans
Intubation
Jugular Veins
Saphenous Vein
Vascular Resistance
Veins*
Dopamine

Figure

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  Figure 1. Hemodynamic changes over time. No significant differences were observed among the three groups. (A) Systolic blood pressure, (B) diastolic blood pressure, (C) mean arterial pressure, (D) heart rate, (E) cardiac output, (F) systemic vascular resistance. CV: cephalic vein; HR: heart rate; GSV: great saphenous vein; EJV: external jugular vein.

Reference

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