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N-retinylidene-N-retinylethanolamine degradation in human retinal pigment epithelial cells via memantine- and ifenprodil-mediated autophagy

Lee JR, Jeong KW

N-methyl-D-aspartate (NMDA) receptors are ionic glutamine receptors involved in brain development and functions such as learning and memory formation. NMDA receptor inhibition is associated with autophagy activation. In this study,...
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The Risk Factors of COVID-19 Infection and Mortality among Older Adults in South Korea

Lee S, Park J, Lee Jr, Lee JY, Kim Bs, Won CW, Lee H, Kim S

Background: This study aimed to identify the risk factors associated with coronavirus disease 2019 (COVID-19) infection and mortality among older adults in South Korea. Methods: Using Korean National Health Insurance...
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Fertility Preservation in Young Women With Breast Cancer: A Review

Hong YH, Park C, Paik H, Lee KH, Lee JR, Han L, Park S, Chung S, Kim HJ

Fertility preservation is a major concern in young patients diagnosed with breast cancer and planning to receive multimodality treatment, including gonadotoxic chemotherapy with or without age-related decline through long-term endocrine...
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Silica-Based Advanced Nanoparticles For Treating Ischemic Disease

Kudaibergen D, Park HS, Park J, Im GB, Lee JR, Joung YK, Bhang SH, Kim JH

Recently, various attempts have been made to apply diverse types of nanoparticles in biotechnology. Silica nanoparticles (SNPs) have been highlighted and studied for their selective accumulation in diseased parts, strong...
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Review the Change of Chronic Disease Care in Korea

Lee JR

Globally, chronic diseases have a high burden and are a significant factor affecting society, such as through economic productivity and deepening social inequality. Deaths from chronic diseases in Korea accounted...
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Microbiology of Human Follicular Fluid and the Vagina and Its Impact on in Vitro Fertilization Outcomes

Kim SM, Won KH, Hong YH, Kim SK, Lee JR, Jee BC, Suh CS

Purpose: The present study aimed to identify microorganisms in follicular fluids and to investigate their association with in vitro fertilization (IVF) outcomes. Materials and Methods: This study was conducted as a...
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Shinjulactone A Blocks Vascular Inflammation and the EndothelialMesenchymal Transition

Jang Ye, Immanuel J, Lee Jr, Jang Yj, Kwon YJ, Kwon HS, Shin JW, Yun S

Objective: The endothelial inflammatory response plays an important role in atherogenesis by inducing nuclear factor (NF)κB-dependent cell adhesion molecule expression and monocyte recruitment. Here, we screened for natural ligands and...
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Correlation of oocyte number with serum anti-Müllerian hormone levels measured by either Access or Elecsys in fresh in vitro fertilization cycles

Jeong HG, Kim SK, Lee JR, Jee BC

Objective: The aim of this study was to assess the correlation of oocyte number with serum anti-Müllerian hormone (AMH) levels measured by two automated methods (Access or Elecsys) in fresh...
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Sperm DNA fragmentation in consecutive ejaculates from patients with cancer for sperm cryopreservation

Kim SK, Paik H, Lee JR, Jee BC

Objective: This prospective consecutive study investigated the variation in sperm DNA fragmentation (SDF) in multiple semen samples from patients with cancer. Methods: Eighty-one patients with various cancers underwent multiple semen collections...
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Ovarian Tissue-Based Hormone Replacement Therapy Recovers Menopause-Related Signs in Mice

Yoo D, Chung N, Yoo J, Song CY, Yang C, Youm HW, Lee K, Jun JH, Lee J, Lee JR

Purpose: In women, menopause manifests with a variety of symptoms related to sex-hormone deficiency. Supplementing steroid hormones with pharmacological drugs has been widely practiced. However, considering the possible complications associated...
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Effect of National Oral Health Screening Program on the Risk of Head and Neck Cancer: A Korean National Population-Based Study

Wee CW, Lee HJ, Lee JR, Lee H, Kwoen MJ, Jeong WJ, Eom KY

Purpose Poor oral health is associated with head and neck cancer (HNC). We evaluated whether a national oral health screening program (OHSP) could reduce the risk of HNC. Materials and Methods Data from...
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Development and Effects of a Mobile Application-based Self-Management Program for Chemotherapy-induced Peripheral Neuropathy in Colorectal Cancer Patients

Oh PJ, Lee JR

Purpose: This study aimed to develop and examine the effects of a mobile application-based self-management program for Chemotherapy-Induced Peripheral Neuropathy (CIPN) in colorectal cancer patients. Methods: This study used a...
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Ovarian tissue cryopreservation and transplantation for fertility preservation

Hong YH, Lee JR

Background: As the number of cancer survivors has increased with advancements in cancer treatment, fertility preservation has become a treatment goal. Ovarian tissue cryopreservation (OTC) and transplantation (OTT) has made...
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Implant assisted removable partial denture with implant surveyed prostheses: A 9-year follow-up

Lee JR, Yoon HI, Kim HS, Sim HY, Han YS

Implant placement may be restricted by anatomical and/or financial limitations in restoring a completely edentulous arch, or the patients’ unwillingness to have extensive surgical procedures. Implant assisted removable partial dentures...
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Metal Ion Releasing Gold Nanoparticles for Improving Therapeutic Efficiency of Tumor Targeted Photothermal Therapy

Park JH, Jung E, Lim H, Lee JR, Joung YK, Yu T, Bhang SH

BACKGROUND: Owing to the tumor-targeted migration capacity of human mesenchymal stem cells (hMSCs), they have been combined with nanoparticles for photothermal therapy. However, the low viability of hMSCs following transplantation...
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Management Status of Patients with Type 2 Diabetes Mellitus at General Hospitals in Korea: A 5-Year Follow-Up Study

Jung JH, Lee JH, Jang HM, Na Y, Choi HS, Lee YH, Kang YG, Kim NR, Lee JR, Song BR, Sim KH

Background: This study aimed to explore the long-term management of diabetes patients in domestic general hospitals by reviewing 2013 and 2018 data on diabetes management status. Methods: Of 1,802 type 2...
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Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR

Han AR, Lee D, Kim SK, Choo CW, Park JC, Lee JR, Choi WJ, Jun JH, Rhee JH, Kim SH, on behalf of Korean Society for Reproductive Medicine (KSRM); Korean Society for Reproductive Immunology (KSRI); Korean Society for Assisted Reproduction (KOSAR)

Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines—including mRNA vaccines—have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination...
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Multilayered Cell Sheets of Cardiac Reprogrammed Cells for the Evaluation of Drug Cytotoxicity

Kwon SP, Song SY, Yoo J, Kim HY, Lee JR, Kang M, Sohn HS, Go S, Jung M, Hong J, Lim S, Kim C, Moon S, Char K, Kim BS

BACKGROUND: Various cell-culture systems have been used to evaluate drug toxicity in vitro. However, factors that affect cytotoxicity outcomes in drug toxicity evaluation systems remain elusive. In this study, we...
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Predictive value of sperm motility before and after preparation for the pregnancy outcomes of intrauterine insemination

Jeong M, Kim SK, Kim H, Lee JR, Jee BC, Kim SH

Objective: This study aimed to investigate sperm motility and its changes after preparation as predictors of pregnancy in intrauterine insemination (IUI) cycles. Methods: In total, 297 IUI cycles from January 2012...
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Altered Gene Expression Profiles in Neural Stem Cells Derived from Duchenne Muscular Dystrophy Patients with Intellectual Disability

Koo J, Park S, Sung SE, Lee J, Kim DS, Lee J, Lee JR, Kim NS, Lee DY

  • KMID: 2519888
  • Exp Neurobiol.
  • 2021 Aug;30(4):263-274.
  • doi: 10.5607/en21008
Intellectual disability (ID) is a neurodevelopmental disorder defined by below-average intelligence (intelligence quotient of
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