Clin Psychopharmacol Neurosci.  2017 Feb;15(1):79-81. 10.9758/cpn.2017.15.1.79.

Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report

  • 1Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
  • 2Health Administration Center, Muroran Institute of Technology, Hokkaido, Japan.
  • 3Department of Biomedical Ethics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
  • 4Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Chiba, Japan.
  • 5Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.


Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical anti-psychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP.


Antipsychotic agents; Disease exacerbation; Receptors, dopamine D2; Recurrence; Schizophrenia
Full Text Links
  • CPN
  • Twitter
  • Facebook
Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: