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Rhabdomyolysis and Neuroleptic Malignant Syndrome Associated with Very Low-dose Antipsychotics in Children and Adolescent

Park JI, Park TW

Along with the field of adult psychiatry, antipsychotic agents are increasingly used in the field of child and adolescent psychiatry. Although neuroleptic malignant syndrome (NMS) and rhabdomyolysis are rare complication...
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Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study

Woo YS, Yoon BH, Jeon BH, Seo JS, Nam B, Lee SY, Jae YM, Jang SH, Eun HJ, Won SH, Lee K, Lee J, Bahk WM

OBJECTIVE: This study was performed to investigate the efficacy and tolerability of blonanserin in schizophrenic patients who were previously treated with other antipsychotics but, due to insufficient response, were switched...
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Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review

Lally J, Sahl AB, Murphy KC, Gaughran F, Stubbs B

The relationship between serum prolactin and bone mineral density (BMD) in schizophrenia is unclear. We conducted a literature review of databases from inception until December 2018 for cross-sectional, case-control, prospective...
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Characteristics of Delirium in Patients with Hearing Disturbances

Jo YT, Joo SW, Lee J, Joo YH

OBJECTIVES: Several studies have delineated the relationship between hearing disturbances and the prevalence or characteristics of psychotic symptoms; however, most of those studies focused on psychiatric patients and not general...
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Association between Thyroid Dysfunction and Severity, Treatment Response in Schizophrenic Inpatients

Jung MJ, Hwang HK, Seo YE, Choi JH

OBJECTIVES: Thyroid hormone deficiency during the neurodevelopmental period can impair brain development and induce psychiatric symptoms. This study examined the association between thyroid dysfunction and the severity of symptoms in...
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Prescribing Pattern of Clozapine and Clinical Factors associated with Discontinuation of Clozapine

Kang SH, Lee HW

OBJECTIVES: Clozapine is the drug of choice in treatment-resistant schizophrenia. However, its use is often delayed and a significant proportion of clozapine treated patients fails to respond and experience potentially...
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Adjunctive Lurasidone Suppresses Food Intake and Weight Gain Associated with Olanzapine Administration in Rats

Reynolds G, Dalton CF, Watrimez W, Jackson J, Harte MK

OBJECTIVE: Lurasidone is an antipsychotic drug that shows a relative lack of weight gain common to many antipsychotics. Aripiprazole and ziprasidone also show little weight gain and can reduce olanzapine-induced...
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Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient

Zulfarina , Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I

Panic disorder (PD) being one of the most intensively investigated anxiety disorders is considered a heterogeneous psychiatric disease which has difficulties with early diagnosis. The disorder is recurrent and usually...
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A Report of Rabbit Syndrome Who Benefited from Sigma 1 Agonist Fluvoxamine

Albayrak Y, Beyazyüz , Abbak O, Altındağ E

Rabbit Syndrome is an uncommon side effect of antipsychotic treatment. Although it is usually associated with typical antipsychotics, it can also be related to atypical antipsychotics. Anticholinergics are the most...
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Clozapine in the Treatment of Aggression in Conduct Disorder in Children and Adolescents: A Randomized, Double-blind, Controlled Trial

Juárez-Treviño M, Esquivel A, Isida LM, Delgado DA, de la O Cavazos ME, Ocañas LG, Sepúlveda RS

OBJECTIVE: This study was conducted to compare the efficacy of clozapine vs. risperidone in the treatment of aggression in conduct disorder in children and adolescents. METHODS: Twenty-four children with conduct disorder...
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Triggers and Outcomes of Falls in Hematology Patients: Analysis of Electronic Health Records

Jung MK, Lee SM

PURPOSE: The goal was to use electronic health records to identify factors and outcomes associated with falls among patients admitted to hematology units. METHODS: This retrospective case-control study included data from...
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The Long-Acting Injectable Antipsychotics in Clinical Practice

Lee K

Symptomatic relapse is observed frequently and often associated with social and/or occupational decline that can be difficult to reverse in patients with schizophrenia. Several atypical antipsychotics, including risperidone, olanzapine, paliperidone,...
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Metabolic Side Effects of Antipsychotic Medication: An Overview

Lee J

Metabolic syndrome (MetS) is a collection of abnormal clinical and metabolic findings that are predictive of cardiovascular disease. The prevalence (approximately 30–40%) of MetS in patients with schizophrenia is higher...
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New Insights into the Molecular and Cellular Mechanism of Antipsychotics

Kim SH

The serendipitous discovery of drugs with antipsychotic action has provided a clue to understanding the pathogenesis of psychotic disorders and to develop so called ‘antipsychotics’ drugs. From the ‘dopamine hypothesis’...
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History and Future of Antipsychotic Drugs

Yi JS

After the discovery of antipsychotic drugs, the nature of clinical practice entered a period of inexorable transition. The advances of psychopharmacotherapy have interacted in complex ways with clinical practice, and...
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Present and Future of Antipsychotics

Kim SH

No abstract available.
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Clinical Features Affecting Antipsychotic Prescription for Delirium Patients

Kim J, Kim MH, Paik SH

OBJECTIVES: The purpose of this study was to investigate the clinical characteristics of antipsychotic medication prescription for the symptom control in patients with delirium. METHODS: One hundred and eighty-five patients referred...
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The Relationship between 10 Years Risk of Cardiovascular Disease and Schizophrenia Symptoms: Preliminary Results

Kilicaslan EE, Karakilic , Erol A

OBJECTIVE: Previous research shows that patients with schizophrenia have increased cardiovascular disease risk than general population. Increased cardiovascular risk in schizophrenia patients have been associated with many reasons such as...
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Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report

Ochi S, Inoue S, Yoshino Y, Shimizu H, Iga JI, Ueno SI

Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails....
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Hypertension Induced by Aripiprazole Use in an Autistic Child Patient

Uzun AD, Sapmaz SY, Öztürk M, Kandemir H

Atypical antipsychotics in children and adolescents are widely used for aggression, emotional variability and psychosis treatment. Aripiprazole is also an atypical antipsychotic that increasingly used in children and adolescents with...
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