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8-Hydroxy-2’-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis

Goh XX, Tang PY, Tee SF

Objective Mental illnesses may be caused by genetic and environmental factors. Recent studies reported that mental illnesses were accompanied by higher oxidative stress level. However, the results were inconsistent. Thus,...
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Obesogenic Behavior and Binge Eating Disorder in an Elderly Female with Schizophrenia

Veeraraghavan V

Eating disorders, like binge eating, have a strong association with schizophrenia. Illness characteristics like disordered eating, cognition, and behavior can lead to eating disorders. Previous research highlighted the neurobiological structural...
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Vibraimage Characteristics of Offenders with Schizophrenia Spectrum Disorder

Lee TS, Jo SN, Lim KO, Jang SY, Cha SM, Han SL

  • KMID: 2517220
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Jun;27(2):124-130.
Objectives:The purpose of this study was to identify characteristic Vibraimage parameters in schizophrenia spectrum and other psychotic disorders. Methods:This study retrospectively analyzed subjects who were referred to the National Forensic Hospital...
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The Comparison of Prevalence and Patterns of Sexual Dysfunction between Patients with Schizophrenia and Healthy Controls

Yoon JH, Back DU, Jae YM, Jang SH, Lee KH, Choi JH

  • KMID: 2517219
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Jun;27(2):112-123.
Objectives:Sexual dysfunction is common in both untreated and treated patients with schizophrenia and known as affecting the quality of life and drug compliance. The primary objective of this study is...
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Acute Colonic Pseudo-obstruction Induced by Neuroleptic Malignant Syndrome

Ryu SJ, Lee JY, Lee JH

A colonic pseudo-obstruction is a disorder that causes abdominal distension and abdominal pain similar to a mechanical obstruction, but there are no structural lesions that can obstruct the gastrointestinal tract....
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Systematic Review of the Neural Effect of Electroconvulsive Therapy in Patients with Schizophrenia: Hippocampus and Insula as the Key Regions of Modulation

Moon SY, Kim M, Lho SK, Oh S, Kim SH, Kwon JS

Objective Electroconvulsive therapy (ECT) has been the most potent treatment option for treatment-resistant schizophrenia (TRS). However, the underlying neural mechanisms of ECT in schizophrenia remain largely unclear. This paper examines...
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Quantitative Resting State Electroencephalography in Patients with Schizophrenia Spectrum Disorders Treated with Strict Monotherapy Using Atypical Antipsychotics

Ozaki T, Toyomaki A, Hashimoto N, Kusumi I

Objective: The effect of antipsychotic drugs on quantitative electroencephalography (EEG) has been mainly examined by the administration of a single test dose or among patients using combinations of other psychotropic...
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Clinical Benefit and Utility of Switching to Aripiprazole Once Monthly in Patients with Antipsychotic Polypharmacy or Long Acting Injectable Antipsychotics for Patients with Schizophrenia in Routine Practice: A Retrospective, Observation Study

Pae CU, Han C, Bahk WM, Lee SJ, Patkar AA, Masand PS

Objective: In a number of controlled clinical trials and naturalistic studies, aripiprazole once monthly (AOM) has been found to be effective and safe as acute and maintenance treatment options for...
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Transcriptome Sequencing Reveals the Potential Mechanisms of Modified Electroconvulsive Therapy in Schizophrenia

Peng W, Tan Q, Yu M, Wang P, Wang T, Yuan J, Liu D, Chen D, Huang C, Tan Y, Liu K, Xiang B, Liang X

Objective Schizophrenia (SCZ) is one of the most common and severe mental disorders. Modified electroconvulsive therapy (MECT) is the most effective therapy for all kinds of SCZ, and the underlying...
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Change of Prescribing Pattern after Clozapine Discontinuation: A Retrospective Chart Review

Kang SH

Objectives: Despite the high discontinuation rate of clozapine in refractory schizophrenia, there is limited evidence regarding the suggested treatment after clozapine discontinuation. Methods: The medical records of 37 patients who discontinued...
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Empathic Tendency and Theory of Mind Skills in Young Individuals with Schizophrenia: Its’ Associations with Self-Reported Schizotypy and Executive Function

Kim SY, Kong W, Koo SJ, Kim H, Park HY, Seo E, Lee E, An SK

Objectives: Social function deficit is known as a core feature of schizophrenia. This study aimed to investigate differences in empathic tendencies and theory of mind (ToM) skills between healthy controls...
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Opinions on the Recovery of Outpatients with Schizophrenia and Their Wills to Recover

Lee JM, Kim CK

Objectives: To examine the opinions regarding recovery and assess their will to recover in outpatients with schizophrenia. Methods: Total 98 stable outpatients with schizophrenia were enrolled. To investigate the outpatients’ opinions...
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Characteristics of Impulsive and Premeditated Aggression Subtypes in Patients with Schizophrenia in South Korea Who Committed a Crime

Kim M, Jo Y, Lee TY, Lim KO, Kwon JS

Objectives: Although the characteristics of different aggression subtypes provide important information in establishing treatment and prevention strategies in schizophrenia patients, limited information is available about the characteristics of the aggressive...
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Current Status of Clozapine for Treatment-Resistant Schizophrenia

Kim SH

Clozapine is the first and most effective atypical antipsychotic drug for treatment-resistant schizophrenia (TRS). After withdrawal of clozapine due to concerns of agranulocytosis, clozapine was reintroduced with a comprehensive safety...
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Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia

Shen J, Shen G, Kim WS, Tsogt U, Liu C, Sui J, Chung YC

Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based...
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Implications of Adult Neural Stem Cell Abnormalities in the Pathophysiological Mechanism of Schizophrenia

Kim Y

Schizophrenia is a syndrome involving positive symptoms, negative symptoms, and cognitive decline due to several causes. The neuropathological findings of schizophrenia are unclear, but the age of onset of schizophrenia...
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Cariprazine Add-on in Inadequate Clozapine Response: A Report on Two Cases

Berardis DD, Rapini G, Olivieri L, Giardini A, Lauretis ID, Serroni N, Orsolini L, Fornaro M, Iasevoli F, Trotta S, Cottura P, Vellante F, Alessandrini M, Giannantonio MD

Cariprazine is a novel antipsychotic drug that exerts partial agonism of dopamine D2 /D3 receptors with preferential binding to the D 3 receptor, antagonism of 5HT2B receptors, and partial agonism...
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Resolution of Persistent Auditory Verbal Hallucinations after Long-term Electroconvulsive Therapy Maintenance: A Case Report of a Patient with Clozapine-resistant Schizophrenia

Chung IW, Kim HS, Kim JH, Jang JH, Kim YS

A 32-year-old woman with schizophrenia and persistent auditory verbal hallucinations (AVHs), which caused continuous suicidal thoughts and depression, was treated with electroconvulsive therapy (ECT) of an acute course followed by...
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Positive Symptoms in Antipsychotic-naïve Schizophrenia are Associated with Increased Body Mass Index after Treatment

Lin SH, Tseng HH, Tsai HC, Chi MH, Lee IH, Chen PS, Chen KC, Yang YK

Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are...
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Effect of Haloperidol and Risperidone on Serum Melatonin and GAP-43 in Patients with Schizophrenia: A Prospective Cohort Study

Maiti R, Mishra BR, Jena M, Mishra A, Nath S

Objective: Serum melatonin, a biomarker of circadian rhythm, can upregulate Growth-associated protein 43 (GAP-43) which is involved in neural regeneration and plasticity. The present study was conducted to investigate the...
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