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Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China

Lin J, Xing B, Tang H, Yang L, Yuan Y, Gu Y, Chen P, Liu X, Zhang J, Liu H, Wang C, Zhou W, Sun D, Chen Y, Chen Z, Huang M, Lin Q, Hu C, Yang X, Huo J, Ye X, Zhou X, Jiang P, Zhang W, Huang Y, Dai L, Liu R, Cai S, Xu J, Zhou J, on behalf of China Asthma Research Network

PURPOSE: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is...
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Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy

Min K, Chung JW, Ha YS, Lee JN, Kim BS, Kim HT, Kim TH, Yoo ES, Kwon TG, Chung SK, Tanaka M, Egawa S, Kimura T, Choi SH

PURPOSE: The purpose of this study was to determine the comparative effectiveness of androgen deprivation therapy (ADT) combined with docetaxel (DTX)-based chemotherapy in Korean and Japanese castration-resistant prostate cancer (CRPC)...
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Dose-Response Association between Smoking Cessation and Arterial Stiffness: The Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) Cohort

Lee GB, Shim JS, Kim HC

BACKGROUND AND OBJECTIVES: Cigarette smoking has been reported to be associated with arterial stiffness. However, the clinical relevance of smoking cessation on arterial stiffness is debatable. Thus, we evaluated whether...
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Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience

Wu A, Graf SA, Burwick N, Grim JE, Dong ZM, Richard RE, Chauncey T

BACKGROUND: Autologous stem cell transplantation (autoSCT) can extend remission of mantle cell lymphoma (MCL), but the management of subsequent relapse is challenging. METHODS: We examined consecutive patients with MCL who underwent...
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HIV-negative plasmablastic lymphoma: report of 8 cases and a comprehensive review of 394 published cases

Li YJ, Li JW, Chen KL, Li J, Zhong MZ, Liu XL, Yi PY, Zhou H

BACKGROUND: Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely...
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Circulating MicroRNAs and T-Cell Cytokine Expression Are Associated With the Characteristics of Asthma Exacerbation

Wardzyńska A, Pawełczyk M, Rywaniak J, Kurowski M, Makowska J, Kowalski M

PURPOSE: Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations of various asthma exacerbation traits with selected serum microRNA (miRNA)...
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MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways

Taka S, Tzani-Tzanopoulou P, Wanstall H, Papadopoulos NG

MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several of these are differentially expressed in asthma as well as in viral...
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Treatment response and disease progression

Holford N

This tutorial defines the concepts of disease progression in the context of clinical pharmacology. Disease progression describes the natural history of disease, such as pain, or biomarker of drug response,...
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New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History

Ko JS

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children,...
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Significant clinicopathologic prognostic factors for bladder recurrence, progression, and cancer-specific survival after surgery among patients with upper urinary tract urothelial carcinoma

Kim SH, Song MK, Joung JY, Chung J, Lee KH, Seo HK

PURPOSE: This study aimed to identify prognostic factors for outcomes after radical nephroureterectomy among patients with upper urinary tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We retrospectively reviewed 184 nonmetastatic cases...
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Multimodality Imaging for the Assessment of Severe Aortic Stenosis

Park SJ, Dweck MR

Aortic stenosis is the most common type of valvular heart disease. Aortic stenosis is characterized both by progressive valve narrowing and the left ventricular remodeling response that ensues. In aortic...
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Cervical Cerebrospinal Fluid Leakage Concomitant with a Thoracic Spinal Intradural Arachnoid Cyst

Han S, Choi SW, Park BS, Lim JW, Kim SH, Youm JY

We encountered a very rare case of spontaneous spinal cerebrospinal fluid (CSF) leakage and a spinal intradural arachnoid cyst (AC) that were diagnosed at different sites in the same patient....
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Progression of Ossification of the Posterior Longitudinal Ligament after Cervical Total Disc Replacement

Ham JS, Kim JH, Yoon JH, Hwang SH, Yoon SH

OBJECTIVE: Total disc replacement (TDR) is frequently performed anterior approaching method for the patients diagnosed with cervical disc herniation. This study aimed to assess the degree of ossification of the...
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Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes

Barber D, Villaseñor A, Escribese

In the last decades have emerged new technological platforms that allow evaluation of genes, transcripts, proteins, or metabolites of a living being, so-called omics sciences. More importantly, new technics for...
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The Feasibility of Spinal Stereotactic Radiosurgery for Spinal Metastasis with Epidural Cord Compression

Kim YJ, Kim JH, Kim K, Kim HJ, Chie EK, Shin KH, Wu HG, Kim IH

PURPOSE: The purpose of this study was to investigate the effectiveness and safety of spinal stereotactic radiosurgery (SRS) in treating spinal metastasis with epidural spinal cord compression (ESCC). MATERIALS AND METHODS:...
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Is It Possible to Discontinue Tumor Necrosis Factor Antagonists after Psoriasis Remission?

Kim B, Maverakis , Raychaudhuri SP

Tumor necrosis factor (TNF) antagonists are highly effective treatments for psoriasis. These agents provide the opportunity to improve disease activity and achieve clinical remission. Despite its efficacy, long-term use of...
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Kidney transplantation in human immunodeficiency virus-infected patients: a report of two cases and a review of the literatures

Hwang HP, Yu HC, Kang KP, Kim W, Park SK, Ku JS, Kim H, Lee S

Human immunodeficiency virus (HIV) infection was traditionally considered an absolute contraindication for transplantation because of concerns about HIV disease progression due to immunosuppression. Since potent antiretroviral therapies (ARTs) have become...
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Sunburn Deteriorated to a Deep Second-Degree Wound in a Healthy Young Female without Risk Factors

Yoon HS, Na YC

Sunburn is the transient inflammatory response of skin caused by excessive exposure to ultraviolet radiation (UVR). The rate of disease progression varies because each individual has different levels of sunburn...
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Autologous hybrid cell fusion vaccine in a spontaneous intermediate model of breast carcinoma

Bird RC, DeInnocentes P, Church Bird AE, Lutful Kabir FM, Martinez-Romero EG, Smith AN, Smith BF

Breast cancer is among the most common malignancies affecting women and reproductively intact female dogs, resulting in death from metastatic disease if not treated effectively. To better manage the disease...
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Ossification of the Posterior Longitudinal Ligament: Surgical Approaches and Associated Complications

Head J, Rymarczuk , Stricsek G, Velagapudi L, Maulucci C, Hoelscher , Harrop J

Ossification of the posterior longitudinal ligament (OPLL) is a rare but potentially devastating cause of degenerative cervical myelopathy (DCM). Decompressive surgery is the standard of care for OPLL and can...
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