Ann Dermatol.  1995 Jan;7(1):34-38. 10.5021/ad.1995.7.1.34.

Sequence Analysis of the Human Tyrosinase Gene in Korean

Abstract

BACKGOUND: Because heterogeneity of the human tyrosinase gene has been reported, it is of vital significance to know the correct nucleotide sequence of tyrosinase in Koreans in order to study the molecular basis of oculocutaneous albinism.
OBJECTIVE
This study was done to analyze the nucleotide sequence of tyrosinase gene in Koreans.
METHODS
All exons were amplified from genomic DNAs and sequenced directly from three healthy Koreans.
RESULTS
The nucleotide sequence of the tyrosinase gene in Koreans encode 511 amino acids with a molecular weight of 58,000.
CONCLUSION
The nucleotide sequence of coding region is the same with that of pHTrl(Shibahara et al. Tohoku J Exp Med 156: 403-414, 1988). As we couldn't observe any polymorphisms in Koreans these results suggested the homogeneity of Korean people.

Keyword

Nucleotide sequence; Tyrosinase gene

MeSH Terms

Albinism, Oculocutaneous
Amino Acids
Base Sequence
Clinical Coding
DNA
Exons
Humans*
Molecular Weight
Monophenol Monooxygenase*
Population Characteristics
Sequence Analysis*
Amino Acids
DNA
Monophenol Monooxygenase
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