J Korean Dent Soc Anesthesiol.  2013 Dec;13(4):161-166. 10.17245/jkdsa.2013.13.4.161.

Dexmedetomidine: Clinical Use

Affiliations
  • 1Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Korea. anekch@pusan.ac.kr

Abstract

Dexmedetomidine is a potent alpha-2-adrenergic agonist, more selective than clonidine, with widespread actions on the mammalian brain. A large body of recent work supports its analgesia and sympatholytic properties. Dexmedetomidine is a useful medication with many clinical applications. The medication has shown efficacy in decreasing the need for opioids, benzodiazepines, propofol, and other sedative medications. Dexmedetomidine has been used effectively for sedation during invasive procedures and in the ICU. Short-term sedation has been shown to be safe in studies, although hypotension and bradycardia are the most significant side effects. Dexmedetomidine is emerging as an effective therapeutic agent in the management of a wide range of clinical conditions with an efficacious, safe profile.

Keyword

Bradycardia; Dexmedetomidine; Hypotension; Sedation

MeSH Terms

Analgesia
Analgesics, Opioid
Benzodiazepines
Bradycardia
Brain
Clonidine
Dexmedetomidine*
Hypotension
Propofol
Analgesics, Opioid
Benzodiazepines
Clonidine
Dexmedetomidine
Propofol

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