J Korean Neuropsychiatr Assoc.  1998 Nov;37(6):1111-1120.

Therapeutic Effect of Risperidone on the Refractory Schizophrenia: a Single-Blinded Comparison with Haloperidol

Affiliations
  • 1Department of Psychiatry, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
  • 2Bugok National Mental Hospital, Bugok, Korea.
  • 3Department of Psychiatry, Dongsuh Hospital, Masan, Korea.
  • 4Department of Psychiatry, Pusan Adventist Hospital, Pusan, Korea.

Abstract


OBJECTIVES
We attempted to investigate clinical efficacy of risperidone a new antipsychotic agent with high safety and without life-threatening side effect such as agranulocytosis, in refractory schizophrenia compared with a haloperidol, well-known antipsychotic agent.
METHODS
Thirty-four subjects(risperidone group 16, haloperidol group 18), who had been proved to be refractory schizophrenics with prospective antipsychotic treatment with at least 2 antipsychotic agents belonging to different chemical groups from each other, were examined with Clinical Global Impression(CGI) and 18-item Brief Psychiatric Rating Scale(BPRS) at 0, 2nd, 4th, 8th, and 12th week from start of drug administration. Those scales were rated in the single-blind manner.
RESULTS
End-point response rate of risperidone was 25%(4 subjects), and that of haloperidol was zero. Difference of the response rates between risperidone and haloperidol was statistically significant. Broader spectrum of symptoms was improved with risperidone treatment than with haloperidol.
CONCLUSION
Risperidone is an antipsychotic agent that clinicians can primarily and effectively try in the refractory schizophrenics with high safety.

Keyword

Risperidone; Refractory schizophrenia; Single-blind comparison; Haloperidol

MeSH Terms

Agranulocytosis
Antipsychotic Agents
Haloperidol*
Prospective Studies
Risperidone*
Schizophrenia*
Weights and Measures
Antipsychotic Agents
Haloperidol
Risperidone
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